This paper examines how the combination of simulated discharge and mean catchment residence time (MRT) may be used to subsume flow path process complexity and provide a simple, scalable evaluative data source for water quantity-quality based conceptual models at the catchment scale. A simple Monte Carlo framework is used to evaluate the identifiability of parameters, and how values of mean resi...

The method of analysis of the first temporal moment (mean residence time) of tracer return data was utilized to investigate the swept volume and fluid velocity between pairs of injection and production wells in the Dixie Valley geothermal field. Calculations were made using a spreadsheet program available from the Idaho National Laboratory. Jointly sponsored industry–government research at the ...

The aim of the study was to determine the apparent volume of distribution (VTOT), total body clearance (CL), fractional clearance, and mean residence time (MRT) of the β-cell hormone amylin. We therefore performed an intravenous injection of 50 μg of human synthetic amylin (amlintide) in nine healthy male subjects during suppression of endogenous amylin release by intravenous somatostatin (0.06...

Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg/kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg/kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental mod...

A campus construction requires wide land space. It indirectly attracts people from out of town to settle around area for various advantageous reasons. These settlers create a variety demands which directly and bring impacts on the increase in demands. This causes an assumption that value is higher outside area. Jalan Williem Iskandar Medan one streets can be classified into areas. The objective...

Soil and epikarst play an important role in the hydrological cycle in karst regions. This paper focuses on investigating the seasonal recharge and mean residence time (MRT) of soil water and epikarst water in a small karst catchment of southwest China. The deuterium contents in precipitation, creek, soil baseflow (direct recharge of the saturated soil water to the stream), epikarst spring, and ...

The bioequivalence of three chemically equivalent paracetamol generic Mexican products (500 mg tablets) was evaluated in 12 healthy volunteers using the American innovator product (Tylenol, McNeil, Fort Washington, PA), as the reference. Single oral doses of each product were administered at 1-week intervals using a 4 x 4 Latin square design balanced for the first residual effect. The total amo...

The problems of the first-passage time (FPT) [1, 2] and the residence time (RT) [3] are very important issues in random walk theory. Moreover, several properties of diffusion and transport in disordered systems are based in this concepts. Here, we do not want to present a survey of the enormous literature in the field of mean firstpassage time (MFPT) and mean residence time (MRT) of random walk...

In a study of the timing mechanism of the chaperonin nanomachine we show that the hemicycle time (HCT) is determined by the mean residence time (MRT) of GroES on the cis ring of GroEL. In turn, this is governed by allosteric interactions within the trans ring of GroEL. Ligands that enhance the R (relaxed) state (residual ADP, the product of the previous hemicycle, and K(+)) extend the MRT and t...

In this study, an open, double-blind, randomized, two-period, two-group crossover design was conducted in 14 healthy volunteers to study the bioequivalence of a fixed-dose generic product. After administration of test or reference products to each volunteer, both active ingredients were determined simultaneously in plasma samples using a developed and validated HPLC-UV method, and pharmacokinet...