conclusions: the combination of plasmid profiling and php techniques revealed the presence of diverse population of vre in sewage treatment plant in tehran. furthermore, the results showed that the php technique is a reliable method in determining the vre clonal diversity. results: all isolates were found to be resistant to erythromycin, ampicillin and ciprofloxacin. the pcr analyses showed tha...

With the rise in multidrug-resistant (MDR) bacterial infections, there has been increasing interest in combinations of ≥2 antimicrobial agents with synergistic effects. We established an MDR bacterial strain library to screen for in vitro antimicrobial synergy by using a broth microdilution checkerboard method and high-throughput luciferase-based bacterial cell viability assay. In total, 39 MDR...

BACKGROUND Assessment of resistance genes is imperative, as they become disseminated to bacterial flora in plants and to the indigenous bacterial community, and thus ultimately contributes to the clinical problems of antibiotic resistant pathogens. OBJECTIVES The research was to assess the antibiotic characteristics and incidence of sul3 genes of Stenotrophomonas maltophilia isolates recovere...

BACKGROUND Considering the importance of hospital wastewaters as potential reservoirs for the dissemination of bacterial pathogens such as Escherichia coli and antibiotic resistance genes in the environment, the need for such information becomes imperative. METHODS E. coli strains were isolated from hospital wastewater sources in Tehran, Iran, over a 24-month sampling period (Jun 2014- Jun 20...

Gram positive pathogens mainly Staphylococcus aureus, Enterococcus and Coagulase Negative Staphylococcus are hospital acquired (HA) pathogens. HA strains are usually multidrug resistant (MDR). Monitoring of these strains is essential in order to control their spread in the hospital environment and transmission to the community. The objectives were to assess the prevalence of Gram positive patho...

tigecycline is a new glycylcycline antibiotic structurally similar to minocycline antibiotic. it has broad spectrum activity, including staphylococcus aureus infections. this is the first study that evaluated the activity of tigecycline against staphylococcus aureus isolated from biological samples in iran. in vitro activity of tigecycline against 160 staphylococcus aureus including 99 methicil...

This study was carried out to detect the distribution of antibioticresistant genes in multi-antibiotic resistant bacteria isolated from Saudi Arabian patients in Taif city. Hence, simple methods were followed herein to isolate and characterize the antibiotic resistant bacteria by the common phenotypic, morphological, biochemical and molecular characters. Out of 200 cultures tested, 60 multidrug...

The use of phages is an attractive option to battle antibiotic resistant bacteria in certain bacterial infections, but the role of phage ecology in bacterial infections is obscure. Here we surveyed the phage ecology in septicemia, the most severe type of bacterial infection. We observed that the majority of the bacterial isolates from septicemia patients spontaneously secreted phages active aga...