kao “lijekova” nesvrhovita, i sada se joπ smatra racionalnim. Takav se stav o vitaminima polako ali sigurno mijenja. Tako je malo poznato da se rijedak oblik megaloblastiËne anemije praÊene dijabetesom melitusom i gluhoÊom moæe lijeËiti visokim dozama tiamina (engl. thiamine-responsive megaloblastic anemia; TRMA) (3). Ovaj je tip anemije autosomska recesivna bolest, u kojoj se prema najnovijim ...

Anemia is one of the most common health problems in primary care setting. Macrocytosis adults defined as a red blood cell mean corpuscular volum >95 fL. Macrocytic anemias are generally classified into megaloblastic or non-megaloblastic anemia. Retrospective descriptive study included 340 samples myelogram received Hematology Labortory belonging to patients admitted Military hospital Avicenn...

The water-soluble micronutrient thiamine is required for normal tissue growth and development in humans. Thiamine is accumulated into cells through the activity of two cell surface thiamine transporters (hTHTR1 and hTHTR2), which are differentially targeted in polarized tissues. Mutational dysfunction of hTHTR1 is associated with the clinical condition of thiamine-responsive megaloblastic anemi...

By CiIAnLI s M. HUGULEY, Jn., JAMES A. BAIN, SHIRLEY L. RIVERS AND ROBERT B. ScoGcINs T HE MAJORITY of anemias associated with a megalohiastic hone marrow respond to vitamin B,2 parenterally. Those which do not respond usually fall into well defined categories of nutritional deficiency, intestinal malahsorption syndromes, pernicious anemia of pregnancy, megaloblastic anemia of infancy or reacti...

This study was carried to identify the causes of pancytopenia and to find out the bone marrow morphology in cases of pancytopenia. It was a cross sectional study conducted over a period of two years in the Department of Pathology, Tribhuvan University Teaching Hospital. Bone marrow aspiration smears of patients fulfilling the criteria of pancytopenia were examined. The data obtained were analyz...

SLC19A2 is a membrane thiamine transporter expressed in a variety of human tissues, including the gastrointestinal tract. Little is currently known about the structure/function relationship of SLC19A2. We examined the effect of introducing mutations in SLC19A2 identical to those found in thiamine-responsive megaloblastic anemia syndrome (TRMA), on functional activity and membrane expression of ...