نتایج جستجو برای: retinoids
تعداد نتایج: 5000 فیلتر نتایج به سال:
Binding affinities of a new and unusual series of retinoic acid analogues to cellular retinoic acid-binding protein, a possible mediator of their biological function in the control of differentiation and tumorigenesis, and to serum albumin, their plasma transport protein, were determined. Also, biological activity of these retinoids in the reversal of keratinization in hamster tracheal organ cu...
Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the...
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guideli...
According to the author, the single most effective component in a skincare regimen for reversal of photoaging is the use of retinoids. Here is a guide to the mechanism and application of various formulations of retinoids, and a comprehensive skin regimen incorporating tretinoin.
1. Abstract 2. Introduction 3. Retnoids and liver fibrosis 3.1. Controversy of retinoids’ effects 3.2. RA-induced TGF-β activation 3.3. Possible mechanisms to explain the controversy 3.4. Protease inhibitor 3.5. Prevention of hepatic fibrosis 3.6. Perspective 4. Retinoids and liver cancer 4.1. Chemoprevention of HCC 4.2. Retinoid refractoriness 4.3. Acyclic retinoid 4.4. Clonal deletion 4.5. Pe...
An early full-term pregnancy significantly reduces the risk of getting breast cancer in women. In animals, this protection can be mimicked by a short-term exposure to physiologic doses of estrogen plus progesterone. Sensitization of p53 and up-regulation of transforming growth factor beta are believed to be important aspects of the mechanism by which protection is imparted. Little is known, how...
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