AIM To review the evidence for optimal oxygen use in preterm infants. RESULTS Clinicians have embraced lower saturation targets to minimize retinopathy of prematurity (ROP). Large randomized trials now have shown that while such targets reduce ROP, neonatal mortality is increased significantly. CONCLUSIONS Preterm infants should be resuscitated with blended oxygen (30-90%) targeted to avoid...

PURPOSE To report the reduction in the incidence and severity of retinopathy of prematurity (ROP) in rural India over a 4-year period following the introduction of improved neonatal care practices. METHODS The Karnataka Internet Diagnosis of Retinopathy of Prematurity program (KIDROP), is a tele-medicine network that screens for ROP in different zones of Karnataka state in rural India. North ...

Retinopathy of prematurity (ROP) examinations in the NICU are necessary to protect vision in premature infants, but the examinations are associated with risk and discomfort. ROP examination risks include adverse effects from mydriatic agents, systemic responses to the stress of examination, and nosocomial infection. Infant discomfort may be lessened by limiting examination length and possibly b...

Supplemental oxygen is a safe and effective treatment for infants with established chronic lung disease who are not at risk of further progression of retinopathy of prematurity (ROP). Oxygen saturations of < 92% should be avoided and a target range of at least 94-96% aimed for. The saturation target range for very preterm infants at risk of developing ROP is more controversial, but the therapeu...

Retinopathy of Prematurity (ROP) is a disorder afflicting prematurely born infants. ROP can be positively diagnosed a few weeks after birth. The goal of this study is to build an automatic tool for prediction of the incidence of ROP from standard clinical factors recorded at birth for premature babies. The data presents various challenges including mixing of categorical and numeric attributes a...

Retinopathy of prematurity (ROP) is related to oxygen-regulated vascular endothelial growth factor and to insulin-like growth factor-I. After premature birth, supplemental oxygen induces a retinal hyperoxic condition with vasoconstriction and to a definitive interruption of retinal vasculogenesis. Peripheral ischemia may stimulate retinal neovascularization and the onset of additional ROP-relat...

Purpose: Document indicators of an increased risk to develop retinopathy of prematurity (ROP) in low birth weight (LBW, < 1500g) infants. Methods: Retrospective chart review. Neonatal characteristics collected were birth weight, gestational age (GA), CRIB (Clinical Risk Index for Babies) score, Apgar score and indicators of respiratory, circulatory and renal instability. Small for gestational a...

OBJECTIVE Insulin-like growth factor I (IGF-I) is necessary for normal development of retinal blood vessels in mice and humans. Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP. DESIGN We conducted a prospective, longitudinal study measuring serum IGF-I ...

Background: Retinopathy of prematurity (ROP) is a common cause of blindness and accounts for up to 10% of childhood blindness in developed countries. Also Before surfactant became available in the NICU, an incidence of 11% to 60% was reported in the VLBW population. However, there are few studies on the incidence of ROP among low-birth-weight (LBW) infants in Iran and the aim of this study is d...