To the Editor: AsCheung et al. (1) report, accurate assessment ofminimal disease is essential to inform the fight to cure children with neuroblastoma. Cheung et al. have exploited gene expression profiling to identify and prioritize targets for the detection of this disease using quantitative reverse transcriptase-PCR (RT-PCR). Eight of 34 genes are prioritized for investigation. Using a simila...

The revolutionary advances in cellular and molecular biochemistry in the last quarter century have provided an unprecedented opportunity for systematic approaches to understand the cancer process. With these new advances and the knowledge acquired as a direct result, an enormous impact has positively affected the clinical areas of cancer prevention, disease management, and treatment of malig-na...

To the Editor: AsCheung et al. (1) report, accurate assessment ofminimal disease is essential to inform the fight to cure children with neuroblastoma. Cheung et al. have exploited gene expression profiling to identify and prioritize targets for the detection of this disease using quantitative reverse transcriptase-PCR (RT-PCR). Eight of 34 genes are prioritized for investigation. Using a simila...

New vessel formation (angiogenesis) is an essential physiological process for embryologic development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the molecular level. Dysregulation of angiogenesis occurs in various pathologies and is one of the hallmarks of cancer. The imbalance of pro- and anti-angiogenic signaling within tumors creates an abnormal vascular network ...

Cardiac hypertrophy is a well-established risk factor for cardiovascular morbidity and mortality. Activation of G(q/11)-mediated signaling is required for pressure overload-induced cardiomyocyte (CM) hypertrophy to develop. We previously showed that among Regulators of G protein Signaling, RGS2 selectively inhibits G(q/11) signaling and its hypertrophic effects in isolated CM. In this study, we...

Cardiac hypertrophy is a well-established risk factor for cardiovascular morbidity and mortality. Activation of Gq/11-mediated signaling is required for pressure overload-induced cardiomyocyte (CM) hypertrophy to develop. We previously showed that among Regulators of G protein Signaling, RGS2 selectively inhibits Gq/11 signaling and its hypertrophic effects in isolated CM. In this study, we gen...

On the basis of their differential location within dermis and discrete changes in gene protein expression, two major fibroblast subtypes (papillary reticular) have traditionally been distinguished. In last 3 years, a number research groups begun to address transcriptomic heterogeneity human skin cells at single-cell level by determining mRNA levels expressed genes through RNA sequencing technol...

Many Regulators of G protein Signaling (RGS) proteins accelerate the intrinsic GTPase activity of Gia and Gqa-subunits [i.e., behave as GTPase-activating proteins (GAPs)] and several act as Gqa-effector antagonists. RGS3, a structurally distinct RGS member with a unique N-terminal domain and a C-terminal RGS domain, and an N-terminally truncated version of RGS3 (RGS3CT) both stimulated the GTPa...