h is the most well-recognized blood group system after ABO, probably because of the dramatic presentation of a fetus suffering hemolytic disease of the newborn (HDN) following maternal alloimmunization to the D antigen. Even individuals not associated with medicine have heard of the “Rh factor” and are aware that it has some importance in pregnancy. The earliest recorded description of the synd...

The Rhesus (Rh) blood group is the most polymorphic human blood group and it is clinically significant in transfusion medicine. Especially, D antigen is the most important and highly immunogenic antigen. Due to anti-D, it is the cause of the hemolytic disease of the newborn and transfusion reaction. About 0.1%-0.5% of Asian people are RhD-negative, whereas in the Thai population, the RhD-negati...

OBJECTIVE To evaluate the diagnostic performance of noninvasive fetal blood group genotyping. DESIGN Descriptive analysis. SETTING Dutch national reference laboratory for pregnancies complicated by alloimmunisation. POPULATION All consecutive alloimmunised pregnant women for whom fetal blood group genotyping of rhesus D, c, E or of K in maternal plasma was performed from 2003 up to 2010. ...

Medea factors or genes are maternal-effects mechanisms, found in many species, in which the mother’s body selectively kills embryos of a certain genotype. Humans have a similar genetic mechanism, the gene RHD which produces Rh-factor involved in blood type. Recently I proposed that RHD acts as a maternal-effects gene that determines handedness (i.e., right handed or non-right handed) in individ...

The mammalian Rh (Rhesus) protein family belongs to the Amt/Mep (ammonia transporter/methylammonium permease)/Rh superfamily of ammonium transporters. Whereas RhCE, RhD and RhAG are erythroid specific, RhBG and RhCG are expressed in key organs associated with ammonium transport and metabolism. We have investigated the ammonium transport function of human RhBG and RhCG by comparing intracellular...

BACKGROUND Health promotion and prevention activities should tackle health inequalities to reduce disparities in health among disadvantaged populations. This study aimed to assess the extent to which the Italian Regions considered health inequalities during the planning of prevention activities, to detect geographical differences and to identify the possible determinants of differences in atten...

Antigens of the Rh blood group system are encoded by 2 homologous genes, RHD and RHCE, that produce 2 red cell membrane proteins. The D-negative phenotype is considered to result, almost invariably, from homozygosity for a complete deletion of RHD. The basis of all PCR tests for predicting fetal D phenotype from DNA obtained from amniocytes or maternal plasma is detection of the presence of RHD...

Clean tests of a small admixture of right-handed quark currents directly coupled to the standard W are still lacking. We show that such non-standard couplings can be significantly constrained measuring the value of the scalar Kπ form factor at the Callan-Treiman point to a few percent. A realistic prospect of such a measurement in K μ3 decay based on an accurate dispersive representation of the...