background: inappropriate activation or blockage of the inhibition of complement system could cause tissue damages in autoimmune diseases particularly rheumatoid arthritis (ra). defect in complement component regulation may cause damages to tissues, on the other hand, or the damaged tissue might affect the unnecessary activation of complement components.   objective: to investigate the expressi...

a number of patients with inflammatory arthritis due to inadequate clinical or laboratory data do not fulfill diagnostic criteria for a clinical disease categories. these patients with initial diagnosis of undifferentiated arthritis (ua) may remit or progress to a definite well- defined condition such as rheumatoid arthritis (ra) or remain as ua with persistence of inflammatory arthritis. the m...

Fluorescein-labelled aggregated human gamma-globulin was found to react in precipitin-type tests with serums of individuals with rheumatoid arthritis. This reagent was also highly reactive and specific for the localization of rheumatoid factor in frozen sections of synovial membranes, lymph nodes, and subcutaneous nodules. In synovial membranes from patients with active rheumatoid arthritis, rh...

To measure rheumatoid factors specific for patients with rheumatoid arthritis an enzyme linked immunosorbent assay (ELISA) was developed to measure rheumatoid factors in human serum that bind a cross-reactive determinant shared on human and other mammalian IgG. Rheumatoid factors that cross link human IgG and sheep IgG in a double binding ELISA were almost completely specific (greater than 99%)...

BACKGROUND Rheumatoid nodules are a common manifestation of rheumatoid arthritis but buccal rheumatoid nodules are extremely rare. The purpose of this study was to report a rare case of a rheumatoid buccal nodule and a review of the literature. METHODS AND RESULTS This case is about a 79-year-old woman with rheumatoid arthritis who was taking methotrexate and hydroxychloroquine, presenting wi...

rheumatoid arthritis is not a rare condition in east iran. we have compiled a study of 76 patients with classic and definite ra in the rheumatology department of ghaem medical school in east iran. all patients were admitted for clinical and serological evaluation. in terms of sex ratio, pattern of joint involvement, severity and nodularity, ra in east iran did not resemble that which has been r...

Rheumatoid arthritis patients are susceptible to interstitial lung disease, and joint manifestations of rheumatoid arthritis usually precede lung involvements by several years. Organizing pneumonia, as the first manifestation of rheumatoid arthritis, is extremely rare, and its clinical features remain currently unknown. We present a case and a literature review of patients who were pathological...

Background: Rheumatoid Arthritis and Chronic Periodontitis are two chronic inflammatory disorders which share a similar pathophysiology. Previously many studies have proposed a relationship between both the diseases. Therefore, the aim of the study was to explore the co-relation between grading of Rheumatoid arthritis and severity of chronic periodontitis in south Indian population. Material An...

Sir, Rheumatoid nodules have been reported to occur in about 20% of patients with chronic rheumatoid polyarthritis (1, 2). In the recent literature, a correlation between treatment of rheumatoid arthritis with methotrexate and the development or worsening of rheumatoid nodules has been suggested (2 ± 4). We describe here the explosive deterioration of rheumatoid nodules during the course of met...

OBJECTIVES To determine the presence of immunoglobulin E-rheumatoid factor in patients with juvenile rheumatoid arthritis and to correlate it with clinical and laboratory parameters. METHODS A multicenter prospective study was carried out from January 1993 to January 1999 with the enrollment of 3 centers of pediatric rheumatology. Ninety-one children with juvenile rheumatoid arthritis diagnos...