Catalytic reactions which involve the cleavage of an sp3 C–H bond adjacent to a nitrogen atom in N-2pyridynyl alkylamines are described. The use of Ru3(CO)12 as the catalyst results in the addition of the sp3 C–H bond across alkene bond to give the coupling products. A variety of alkenes, including terminal, internal, and cyclic alkenes, can be used for the coupling reaction. The presence of di...

NADPH oxidases (NOXs) constitute a family of enzymes generating reactive oxygen species (ROS) and are increasingly recognized as interesting drug targets. Here we investigated the effects of 10 phenothiazine compounds on NOX activity using an extensive panel of assays to measure production of ROS (Amplex red, WST-1, MCLA) and oxygen consumption. Striking differences between highly similar pheno...

The feasibility of employing azulene-like molecules as a new type of high performance substitution-free molecular rectifier has been explored using NEGF-DFT calculation. The electronic transport behaviors of metal-molecule-metal junctions consisting of various azulene-like dithiol molecules are investigated, which reveals that the azulene-like molecules exhibit high conductance and bias-depende...

in this paper, we study some ring theoretic properties of the amalgamated duplication ring $rbowtie i$ of a commutative noetherian ring $r$ along an ideal $i$ of $r$ which was introduced by d'anna and fontana. indeed, it is determined that when $rbowtie i$ satisfies serre's conditions $(r_n)$ and $(s_n)$, and when is a normal ring, a generalized cohen-macaulay ring and finally a filter ring.

Flavanones, Catabolites, Peroxidases, Degradation, Substitution Pattern Peroxidases were shown to be responsible for the degradation of flavanones as occuring after application of these substrates to plant cell suspension cultures. — Comparative studies with various flavanones and horseradish peroxidase showed that only 4'-hydroxyflavanones will be catabolized peroxidatically. — Intensive analy...

Stereospecific nucleophilic substitution at the C-4α position of 2α-chloro-2'(2',6')-(di)halogenopicropodophyllotoxin derivatives with carboxylic acids mediated by BF3·Et2O was described. Interestingly, this stereoselective products were completely controlled by the reaction time. That is, if the reaction time was prolonged to 24.5-31 h, the resulting compounds were all transformed into the unu...

An operationally simple, high yielding three-step cascade process is described for the direct conversion of indole-tethered ynones into functionalized quinolines. A single “multitasking” thiol reagent used to promote a dearomatizing spirocyclization, nucleophilic substitution, and one-atom ring expansion reaction under remarkably mild conditions. In addition, novel route thio-oxindoles describe...

in this paper, we introduce a class of $j$-quasipolar rings. let $r$ be a ring with identity. an element $a$ of a ring $r$ is called {it weakly $j$-quasipolar} if there exists $p^2 = pin comm^2(a)$ such that $a + p$ or $a-p$ are contained in $j(r)$ and the ring $r$ is called {it weakly $j$-quasipolar} if every element of $r$ is weakly $j$-quasipolar. we give many characterizations and investiga...

A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...

in this paper, we investigate various kinds of extensions of twin-good rings. moreover, we prove that every element of an abelian neat ring r is twin-good if and only if r has no factor ring isomorphic to z2  or z3. the main result of [24] states some conditions that any right self-injective ring r is twin-good. we extend this result to any regular baer ring r by proving that every element of a...