Teleost rod photoreceptors elongate in the light and shorten in darkness. We are investigating the role of cAMP-dependent protein kinase (PKA), phosphatases and target phosphoproteins in the regulation of photoreceptor cell shape. Preparations of rod fragments, consisting of the motile inner segment with attached photosensory outer segment (RIS-ROS), undergo light-stimulated elongation in cultu...

MULTIPLE SCLEROSIS MSJ JOURNAL With the increasing use of brain magnetic resonance imaging (MRI) by clinicians, researchers and even companies that carry out health checkups the finding of asymptomatic intracranial abnormalities of potential clinical significance has risen tremendously. 1 In a recent meta-analysis, the prevalence of neoplastic and non-neoplastic incidental findings on brain MRI...

INTRODUCTION With the development of magnetic resonance imaging (MRI) and publications about radiologically isolated syndrome (RIS), a lot of patients are referred to multiple sclerosis (MS) tertiary centers to confirm diagnosis of RIS or MS when brain T2 abnormalities are identified, whatever their characteristics. We evaluate prospectively the occurrence of RIS or MS and sensitivity, specific...

Radioimmunoscintigraphy (RIS) using human monoclonal antibodies offers the important clinical advantage of repeated imaging over murine monoclonal antibodies by eliminating the cross-species antibody response. This article reports a Phase I-II clinical trial with Tc-99m-labeled, totally human monoclonal antibody 88BV59H21-2 in patients with colorectal carcinoma. The study population consisted o...

BACKGROUND This study aims to determine the effectiveness of blonanserin (BNS) on the cognitive and social functions of patients with schizophrenia compared with risperidone (RIS) during acute-phase (8-week) treatment. METHODS A total of 39 schizophrenia inpatients were included in this study. The subjects received either BNS (N=20) or RIS (N=19), and the clinical responses were evaluated per...

OBJECTIVE Increasing evidence indicates that the thalamus may be a location of early neurodegeneration in multiple sclerosis (MS). Our objective was to identify the presence of gray matter volume loss and thinning in patients with radiologically isolated syndrome (RIS). METHODS Sixty-three participants were included in this case-control study. Twenty-one patients with RIS were age- and sex-ma...

This paper investigates to what extent child second language (L2) acquisition is similar to first language (L1) acquisition. The focus is on the nature of root infinitives (RIs) produced by children, namely root declarative clauses whose main verb is either a past participle or an infinitive, whereas a finite form is required in the target language (e.g. papa partir 'daddy leave-INF' instead of...

A Railway Interloc king System (RIS) is an Embedded System (namely a Supervisory Control System) that ensures the safe op eration of the devic es in a R ailway Station. Of course a RIS is a Safet y Critical System. In this p aper we explore the p ossibility of integrating automatic formal veri cation methods in a given industry RIS design ow. The main obstructions to be over come in our work ar...

One of the important modes of pre-mRNA post-transcriptional modification is alternative splicing. Alternative splicing allows creation of many distinct mature mRNA transcripts from a single gene by utilizing different splice sites. In plants like Arabidopsis thaliana, the most common type of alternative splicing is intron retention. Many studies in the past focus on positional distribution of r...