Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Ligand selectivity of tartrate vs nicotinamide in a water-methanol system has been observed the crystallization Mn(II) and Cd(II) complexes. These complexes were crystallized at room temperature by layered solution technique using mixture solvent M(II):tartrate:nicotinamide (M = Mn, Cd) molar ratio 1:1:2. Complexes M(II)-nicotinamide M(II)-tartrate also prepared for data comparison. Analysis cr...

Objective: In an attempt to optimize the anti-Alzheimer effect, rivastigmine-loaded chitosan nanoparticles were developed in order target of brain through skin permeation. Methods: Rivastigmine-loaded chitosan-tripolyphosphate prepared by modified ionic gelation method using tween 80 surfactants different batches with variable chitosan/cross-linker ratios, desirability factors applied choose op...

In the title compound, {[Ga(2)(C(4)H(4)O(6))(2)(OH)(2)]·2H(2)O}(n), the Ga(III) atom is located on a twofold rotation axis and is six-coordinated by two O atoms from bridging hydroxide groups and four O atoms from two symmetry-related tartrate units in a slightly distorted octa-hedral environment. Each tartrate unit binds to two Ga(III) atoms as a bis-chelating bridging ligand by two pairs of h...

The title compound, {[Cd(C(4)H(4)O(6))]·0.167H(2)O}(n), adopts a three-dimensional network structure in which each Cd(II) ion is chelated by two pairs of carboxyl-ate and hydroxyl O atoms from two tartrate anions, and is additionally linked to two O atoms of two carboxyl-ate groups that are not involved in chelation. The asymmetric unit has four independent cadmium atoms, two of which lie on sp...

The title Schiff base ligand, C(20)H(20)Cl(2)N(2), was prepared by condensation of commercially available p-chloro-benzalde-hyde and (R,R)-1,2-diammonium-cyclo-hexane mono-(+)-tartrate. The cyclo-hexane ring adopts a chair conformation. The dihedral angle between the two aromatic rings is 62.52 (8)°. The crystal structure is stabilized by an inter-molecular C-H⋯Cl hydrogen bond.

The primary objective of the open-label extension was to evaluate the long-term safety and tolerability of a transdermal rivastigmine patch up to 1 year, as a novel approach to treatment in Alzheimer disease. This was a 28-week extension to a 24-week, double-blind, double-dummy, placebo-controlled, and active-controlled study evaluating rivastigmine patches [9.5 mg/24 h (10 cm2) and 17.4 mg/24 ...

Pharmacologic treatments for Alzheimer's disease include the cholinesterase inhibitors donepezil, galantamine, and rivastigmine. We reviewed their evidence by searching MEDLINE, Embase, The Cochrane Library, and the International Pharmaceutical Abstracts from 1980 through 2007 (July) for placebo-controlled and comparative trials assessing cognition, function, behavior, global change, and safety...

In the crystal of the title hydrated salt, C6H7N4 (+)·C4H5O6 (-)·0.5H2O, the bi-imidazole monocation, 1H,1'H-[2,2'-biimidazol]-3-ium, is hydrogen bonded, via N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds, to the hydrogen tartrate anion and the water mol-ecule, which is located on a twofold rotation axis, forming sheets parallel to (001). The sheets are linked via C-H⋯O hydrogen bonds, forming a three-d...