BACKGROUND Modeling studies using hypothetical polygenic risk data can be an efficient tool for investigating the effectiveness of downstream applications such as targeting interventions to risk groups to justify whether empirical investigation is warranted. We investigated the assumptions underlying a method that simulates risk data for specific values of the area under the receiver operating ...

We introduce a new smooth estimator of the ROC curve based on log-concave density estimates of the constituent distributions. We show that our estimate is asymptotically equivalent to the empirical ROC curve if the underlying densities are in fact log-concave. In addition, we empirically show that our proposed estimator exhibits an efficiency gain for finite sample sizes with respect to the sta...

-Receiver Operating Characteristic (ROC) curves are used to describe and compare the accuracy of diagnostic test or the ability of a continuous biomarker in discriminating between the subjects into healthy or diseased cases in medical field. The most familiar form of ROC curve is Bi-normal (Gaussian) ROC curve model, which assumes that the test scores or a monotone transformation of the test sc...

The receiver operating characteristics (ROC) curve is a standard statistical tool to characterize the accuracy of diagnostic tests when test results are continuous. It provides a complete description of test performance and a meaningful way to compare the performances of different tests. The empirical (nonparametric) ROC curve is the most popular estimator of the ROC curve. Semiparametric estim...

The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker. The ROC, PPV and NPV curves are often estimated empirically to avoid assumptions about the distributional form of the biomarkers. Recently, there has been a push to incorporate group se...

Uplift modeling is a classification method that determines the incremental impact of an action on a given population. Uplift modeling aims at maximizing the area under the uplift curve, which is the difference between the subject and control sets’ area under the lift curve. Lift and uplift curves are seldom used outside of the marketing domain, whereas the related ROC curve is frequently used i...

Receiver Operator Characteristic (ROC) curves are commonly applied as metrics for quantifying the performance of binary fault detection systems. An ROC curve provides a visual representation of a detection system’s True Positive Rate versus False Positive Rate sensitivity as the detection threshold is varied. The area under the curve provides a measure of fault detection performance independent...