background: several echocardiographic markers have been introduced to assess the left ventricular (lv) mechanical dyssynchrony. we studied dyssynchrony markers and the latest lv activation site in heart failure patients with and without left bundle branch block (lbbb). methods: conventional echocardiography and tissue velocity imaging were performed for 78 patients (lv ejection fraction ≤ 35%),...

Experiments have been conducted in 7-rod vertical bundles within circular shell. Buoyancy supports the forced flow in one and opposes it in the other. The Reynolds number range nominally covered 900 to 30000; but no distinct transition was observed. The behaviour is explained through a porous medium model. Procedures for estimating bundle-average permeability and fRe values on the basis of poro...

We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and r...

The cofilin-actin rod stress response is an actin cytoskeletal dynamic arrest that occurs in cells under a variety of stress conditions. Upon stress, the rapidly activated cofilin saturates actin filaments causing them to bundle into rod structures in either the nucleus or cytoplasm, halting actin polymerization and thus freeing ATP. Importantly, these rods dissociate quickly following relief o...

SUMMARY Taxonomy: Turnip vein-clearing virus (TVCV) is a member of subgroup 3 of the Tobamovirus genus and is thus a member of the alphavirus-like supergroup of positive sense RNA-containing viruses. Physical properties: Virions, typical of tobamoviruses, are rod-shaped and consist of a single species of four-helix bundle capsid proteins of 17 kDa helically arranged around a 6.3 knt RNA which a...