Sorafenib is a multi-targeted kinase inhibitor, which is the current standard treatment for advanced hepatocellular carcinoma (HCC). Only one case of radiation recall dermatitis (RRD) associated with sorafenib has been reported so far. Our patient with recurrent HCC was treated with palliative radiotherapy (RT) for the chest wall mass. Sorafenib at 400 mg twice daily was begun on the day follow...

To avoid the problem of wireless broadcast storm, the Random Rebroadcast Delay (RRD) approach was introduced in the process of flooding-based route discovery in DSR and AODV protocols. We identify the “next-hop racing” phenomena due to the RRD approach and propose a Positional Attribute based Nexthop Determination Approach (PANDA) to address this problem. Based on positional attributes such as ...

Rhegmatogenous retinal detachment (RRD) is a vision-threatening disorder. Although successful repair of RRD, incomplete visual recovery, color vision defects, or persistent metamorphopsia may be still persist. Recent advances in retinal imaging have improved resolution to survey retinal pathologic changes. Spectral-domain optical coherence tomography (SD-OCT) is a non-contact real-time system w...

Sorafenib is widely used for unresectable and metastatic hepatocellular carcinomas. Radiation recall dermatitis (RRD) is an acute inflammatory reaction confined to previously irradiated skin that occurs after the administration of certain drugs. RRD after sorafenib treatment is rare; five cases have been reported thus far. We describe a 44-year-old man irradiated for chest wall bone metastasis ...

Background—The reverse rate dependence (RRD) of actions of IKr-blocking drugs to increase the action potential duration (APD) and beat-to-beat variability of repolarization (BVR) of APD is proarrhythmic. We determined whether inhibition of endogenous, physiological late Na current (late INa) attenuates the RRD and proarrhythmic effect of IKr inhibition. Methods and Results—Duration of the monop...

Herein, we report a case of nontraumatic bilateral rhegmatogenous retinal detachment (RRD) during external beam radiotherapy for nonocular tumor, presented as an observational case study in conjunction with a review of the relevant literature. A 65-year-old male was referred to our hospital due to bilateral RRD. He underwent a biopsy for a tumor of the left frontal lobe 4 months prior to presen...

PURPOSE To investigate the clinical features and molecular causes of autosomal dominant rhegmatogenous retinal detachment (RRD) in two large families. METHODS Clinical examination and linkage analysis of both families using markers flanking the COL2A1 gene associated with Stickler syndrome type 1, the loci for Wagner disease/erosive vitreoretinopathy (5q14.3), high myopia (18p11.31 and 12q21-...

R hegmatogenous retinal detachment (RRD) can be surgically treated with scleral buckling (SB), pars plana vitrectomy (PPV), or a combination of the 2 procedures. Responses to the American Society of Retina Surgeons’ Preferences and Trends Survey suggest a declining use of SB over the past decade. The biggest reason for this trend is advances in the techniques and instrumentation used to repair ...

PURPOSE To modify existing experimental models to simulate the typical clinical presentation of human rhegmatogenous retinal detachment (RRD), namely an RD caused by a retinal break, in a phakic eye, with a posterior vitreous detachment (PVD); to model RRD in a species that is anatomically similar to humans; and to characterize the glial cell response to RRD. METHODS Mixed-breed pigs underwen...

Quantitative microbiological models predicting proliferation of microorganisms relevant for food safety and/or food stability are useful tools to limit the need for generation of biological data through challenge testing and shelf-life testing. The use of these models requires quick and reliable methods for the generation of growth data and estimation of growth parameters. Growth parameter esti...