Mutational analysis of the histone H3 N-terminal region has shown it to play an important role both in chromatin function in vivo and nucleosome dynamics in vitro. Here we use a library of mutations in the H3 N-terminal region to investigate the contribution of this region to the action of the ATP-dependent remodelling enzymes Chd1, RSC and SWI/SNF. All of the enzymes were affected differently ...

People need to understand why an instance of suffering occurred and what purpose it might have. One widespread account of suffering is a repressive suffering construal (RSC): interpreting suffering as occurring because people deviate from social norms and as having the purpose of reinforcing the social order. Based on the theorizing of Emile Durkheim and others, we propose that RSC is associate...

Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies showed that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or rSC). The previous results are consistent with two hypotheses. Attention–related changes in rate and rSC might be linked (perhaps through ...

Chromatin remodeling complexes (remodelers) are large, multisubunit macromolecular assemblies that use ATP hydrolysis to alter the structure and positioning of nucleosomes. The mechanisms proposed for remodeler action on nucleosomes are diverse, and require structural evaluation and insights. Previous reconstructions of remodelers using electron microscopy revealed interesting features, but als...

By a limited proteolysis with thermolysin, rye seed chitinase-a (RSC-a) was separated into a N-terminal c}'steine-rich chitin-binding (CB-) domain (48 residues) and a cata])'tic (Cat-) domain (254 residues). The h)'drolytic activity of the isolated Cat-domain toward sotuble glycolchitin, was similar to that of RSC-a, but that toward insolub]e cot]oidal chitin was 28'M, of that of RSC-a. Five di...

Spatial navigation is a core cognitive ability in humans and animals. Neuroimaging studies have identified two functionally defined brain regions that activate during navigational tasks and also during passive viewing of navigationally relevant stimuli such as environmental scenes: the parahippocampal place area (PPA) and the retrosplenial complex (RSC). Recent findings indicate that the PPA an...

This paper proposes a robust nonlinear feedback control approach of a residential Savonuis Vertical Axis Wind Turbine (VAWT) based on Double Fed Induction Generator (DFIG) and connected to a powerful grid. However, as the studied system is non linear, it is difficult to be controlled using such traditional methods. Thus, in order to achieve an instantaneous control of both stator active and rea...

Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-RSC infusion of the CB1R antagonist AM251 impaired, and the agonist CP55940 improved, long-term me...

This paper presents the state space modelling of doubly fed induction generator (DFIG) for small signal stability assessment. The gains of PI controller in torque and voltage control loop of rotor-side converter (RSC) are optimized by particle swarm optimization (PSO) to improve the dynamic performance of DFIG. These optimized parameters results in improved damping of DFIG and minimizes the osc...