The paper deals with a review article of nervous system disorders caused by rubella virus (RV) infection. The diseases are categorized as acute and chronic, the former consists of acute encephalitis and peripheral neuropathy, and the latter congenital rubella syndrome and progressive rubella panencephalitis. Acute rubella encephalitis occurs one case per 6,000 rubella patients either at viremia...

Primary infection of HEp-2 cells with rubella virus resulted in non-cytophatic long-term persistent infection. During four years of persistence the virus was produced in sufficient quantities (up to 6 logs PFU/ml) and did not differ from the parental variant in its pathogenicity for BHK-21 or RK-13 cells, or hemagglutinating activity, but formed smaller plaques. Persistent virus preserved the o...

A congenital rubella syndrome (Box 1) is rare in Canada, it does still occur. Many women immigrate to Canada from countries without a rubella vaccination program and may not have adequate immunity. In 2002, only 124 (58%) of 214 countries or territories around the world had implemented a rubella vaccination program. An Australian study found that women born in Asia, sub-Saharan Africa and South...

Five cases of asymptomatic maternal reinfection with rubella are described that occurred in England and Wales during 1985-8 and resulted in intrauterine infection. The criteria for diagnosing reinfection are described. In four cases the rubella contact was with the woman's own children. Two women had therapeutic abortions, rubella virus being recovered from the products of conception, and three...

MATERIALS AND METHODS Virus Two strains of rubella virus were used, Judith (McCarthy & Taylor-Robinson, 1965) and Thomas, the latter having been isolated at St Thomas's Hospital in 1966 from an infant with congenital rubella. Judith was propagated in both RK 13 and BHK-21 cell cultures. Since its original isolation, Thomas had been passed eight times in RK 13 and BHK-21 cell cultures. Titres of...

A modified rubella virus plaque neutralization test for measuring rubella antibody was developed based on the potentiation of the virus-antibody complex by heterologous anti-immunoglobulin. The test is highly sensitive, yielding titers on the average 50 to 100 times higher than the haemagglutination inhibition test or the conventional plaque neutralization test. The sensitivity of this enhanced...

purpose: to evaluate the etiology of cataracts in children less than 3 years of age particularly the association of rubella virus infection and galactosuria with congenital cataracts at khalili hospital, shiraz-iran from 2003 to 2006. methods: this prospective study included 46 patients less than 3 years undergoing lensectomy for the management of significant cataracts. lens aspirate specimens ...

Viral antibody-titres were measured in 28 patients with Bell's palsy seen in Baghdad. These cases were selected to include only those seen within 24 hours from onset. No association with recent viral infection other than rubella virus was demonstrated. Four cases showed immunological evidence of simultaneous rubella virus infection but without other clinical evidence of the disease.

Overview of Persistent Rubella Infection and Autism Induction in Pregnancy Idea 3 Why Might Vaccine-Strain Rubella Virus Persist in Some Females? 3 Questions about RA27/3 Strain of Rubella Vaccine 4 What Data in the Literature & What Facts May Support these Ideas? 4-9 Concluding Remarks & Requests 9 A Final Data Point & Questions 10 References 11 Appendix A: Information provided from CBER/FDA o...

Primary cultures of rabbit (New Zealand white) embryo cells support growth of rubella virus. Distinct cytopathic changes are discernible within 6 to 8 days after inoculation. This cell system has been successful for the recovery of rubella virus from clinical materials and the demonstration of neutralizing antibody in patient serum.