Rupture, bond breaking, or extraction from a deep and narrow potential well requires considerable force while producing minimal displacement. In thermally fluctuating systems, there is not a single force required to achieve rupture, but a spectrum, as thermal forces can both augment and inhibit the bond breaking. We demonstrate measurement and interpretation of the distribution of rupture force...

About 15 years ago, the steered molecular dynamics (SMD) was used to probe binding of ligand to biomolecule surfaces but in terms of drug design this approach has only recently attached attention of researchers. The main idea of using SMD to screen out leads is based on the hypothesis that the larger is the force needed to unbind a ligand from a receptor the higher its binding affinity. Thus, i...

The study of liquid force has a special meaning to industrial manufacturing. By taking the bridges between equal and unequal particles as objects, force-displacement curves were measured recorded by using novel Nano UTM T150 tensile system. influences diameter, diameter ratio, volume, surface tension on force-distance curve, maximum force, rupture distance compared sorted. results show that bot...

Viruses are biological agents with great potential in the field of nanotechnology. Nowadays, their amazing properties are starting to be unveiled using physical techniques like the atomic force microscope. In this study, we have used a Virtual AFM, i.e., a simulator that mimics a typical AFM nanoindentation experiment, to study the mechanical properties of viral shells. In particular, with our ...

building pounding occurs between two adjacent buildings with small gap or without sufficient separation distance. it leads to damage buildings during earthquake due to impact. many researchers have investigated building pounding based on impact force reduction and energy dissipation increase, when two buildings collide with each other. in numerical investigations, using specific link element, i...

tomato is one of the sensitive fruits to mechanical impacts and physical tensions. the mostmechanical damages arise from handling which results in reducing tomato quality. in this study,impact energy effect has been studied in 3 different levels 0, 0.14 and 0.25 j by a pendulum impactapparatus, on changes of physicochemical properties of tomato, hybrid variety shiva f1, includingripening factor...

this work is conducted to obtain mechanical properties of microtubule. for this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha, and beta-beta dimers was calculated using the molecular dynamic simulation. force-distance diagrams for these dimers were obtained using the relation between potential energy and force. afterwards, instead of each tubulin, one sphere with 55 kda weight ...

A theory of the unzipping of double-stranded (ds) DNA is presented, and is compared to recent micromanipulation experiments. It is shown that the interactions which stabilize the double helix and the elastic rigidity of single strands (ss) simply determine the sequence dependent ≈ 12 pN force threshold for DNA strand separation. Using a semi-microscopic model of the binding between nucleotide s...

Subject to a compressive membrane force, a solid film on a liquid layer may form wrinkles. When the solid film is very thin, surface stresses contribute to the membrane force. When the liquid layer is very thin, the two interfaces bounding the liquid interact with each other through forces of various physical origins. We formulate the free energy of the solid-on-liquid structure, and carry out ...

rupture and wrinkling are two prevalent phenomena that happen in hydro-forming process. many efforts have been made to achieve the upper and lower bounds for the pressure related to rupture and wrinkling of sheet, respectively. the aim of this investigation is to improve the upper bound of fluid pressure in hydro-forming process by hemispherical punch. in this article, analytical study of the u...