Objective(s): Rutin is a flavonoid with potent antioxidant property, which exhibited cytoprotective effects in several models of neuronal injury. This work aimed to examine whether rutin can protect neurons against oxidative DNA damage caused by serum/glucose deprivation (SGD) as an in vitro model of neurodegeneration and ischemia. Materials and Metho...

An electrochemical method based on a directly electrochemically reduced graphene oxide (ERGO) film coated on a glassy carbon electrode (GCE) was developed for the rapid and convenient determination of rutin in plasma. ERGO was modified on the surface of GCE by one-step electro-deposition method. Electrochemical behavior of rutin on ERGO/GCE indicated that rutin underwent a surface-controlled qu...

To prevent hydrate plugging conditions in the transportation of oil/gas in multiphase flowlines, one of the key processes to control is the agglomeration/deposition of hydrate particles, which are determined by the cohesive/adhesive forces. Previous studies reporting measurements of the cohesive/adhesive force between hydrate particles used cyclopentane hydrate particles in a low-pressure micro...

BACKGROUND Rutin, a polyphenolic flavonoid, was investigated for its protective effects against the KBrO(3) induced renal injuries in rat. METHODS Group I was control (untreated), group II was given saline 0.5 ml/kg bw (0.9% NaCl), group III was administered KBrO(3) (20 mg/kg bw) intragastric twice a week for four weeks. Rutin was administered to group VI (50 mg/kg bw) and Group V (70 mg/kg b...

Phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. It has been established that these compounds can scavenge free radicals produced in the body. Because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

BACKGROUND Reperfusion therapy used in the treatment of cerebral ischemia often causes reperfusion neurological injury. Multiple pathological processes are involved in this injury including oxidative stress and components of the inflammatory response appear to play key roles in these deleterious effects. Thus new therapeutic strategies aimed at neutralization of OS-induced neurotoxicity support...

In this work and in order to consider theoretically the effect of gas hydrates on the mechanical properties of their host sediments, hydrate fraction was introduced as a state variable in the framework of a Critical State model. For the proposed model, the process of de-structuration and softening of natural clay was considered as a proxy for the gas-hydrate-bearing-sediments behaviour. The dev...

−Segregation and deposition of hydrate particles observed in flowloop experiments are required to be investigated more thoroughly to understand the hydrate plugging mechanism in offshore flowlines. We used natural gas as gas phase and selected three different systems as liquid phase, which are pure water only, kinetic hydrate inhibitor added aqueous solution, and water+decane mixture, respectiv...

Gas hydrate blockage in pipelines during offshore production becomes a major problem with increasing water depth. In this work, a series of experiments on gas hydrate formation in a flow loop was performed with low flow rates of 0.33, 0.66, and 0.88 m/s; the effects of the initial subcooling, flow rate, pressure, and morphology were investigated for methane hydrate formation in the flow loop. T...

The presence of structure H (sH) methane hydrate in natural environments, in addition to the well-known structure-I (sI) and II (sII) hydrates, has recently been documented. Methane in the presence of condensates (C5-C7) forms sH hydrate at lower pressure than the sI hydrate. Thus, the occurrence of sH methane hydrate is likely to have both beneficial and negative practical implications. On the...