FOXM1 is a pro-proliferative transcription factor that promotes cell cycle progression at the G1-S, and G2-M transitions. It is activated by phosphorylation usually mediated by successive cyclin - cyclin dependent kinase complexes, and is highly expressed in sarcoma. p53 down regulates FOXM1 and FOXM1 inhibition is also partly dependent on Rb and p21. Abnormalities of p53 or Rb are frequent in ...

BACKGROUND Central nervous system is a very rare site of Kaposi's sarcoma in acquired immunodeficiency syndrome. Kaposi's sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral therapy, highly active against human immunodeficiency virus type-1, has caused a dramatic reduction of ...

Background Ewing’s sarcoma family is a group of small round cells tumors. The aim of this study is to evaluate clinicopathologic characteristics and outcome of Ewing’s sarcoma in children and adolescents in Yazd, Iran. Materials and Methods All patients under 19 years with documented pathology of Ewing’s sarcoma family tumor who referred to Shahid Ramazanzadeh Radiotherapy center between 2...

Uterine sarcomas are very unique tumors with mesodermial origin and accounting for 2-6% of uterine cancers. In general, uterine sarcomas are the most malignant tumors of the uterus. Their usual histologic types are endometrial estromal sarcoma, lieomyosarcoma and malignant mixed mullerian tumor or carcinosarcoma In this case report, a 19 year old woman with chief complaint of abnormal ute...

        Ewing's sarcoma is a relatively common malignant bone tumor that typically occurs in long bone diaphyses of adolescents and young adults of 10-30 years old. Often times, all Ewing's sarcoma of bone have radiographic abnormalities. Diagnosis is usually delayed and can be misdiagnosed as osteomyelitis. Bone to bone metastasis occurs, but soft tissue retro bulbar metastas...

Soft-tissue sarcoma (STS) is represented by a heterogeneous group of rare malignancies with various molecular oncogenesis. Therapies targeting DNA repair pathways in STS have achieved minimal progress, potentially due to the lack biomarker(s) beyond histology subtype. In this report, we comprehensively analyzed expression profiles 100 liposarcomas (LPSs), most common subtype, comparison 21 adip...

HIV/AIDS infection in Bulgaria has spread over about 1200 registered patients and it is supposed that the number of the undetected cases is four times higher. Kaposi’s sarcoma is rarely observed in our country and no cutaneous-mucosal dissemination is reported for the time being. Aim: The aim of the study is to present a case of disseminated Kaposi’s sarcoma in a HIV/ AIDS patient who underwent...

  Periarticular cyst and cystic soft tissue lesion around the knee are common. Synovial sarcoma is a rare and malignant soft tissue tumor accounting for approximately 5% of soft tissue sarcoma. A case is presented where a lesion adjacent to the joint line of the knee was diagnosed clinically and on imaging as a meniscal cyst. MRI signal was homogenous and no concomitant meniscal tears were seen...

The creatine/creatine kinase system decreases drastically in sarcoma. In the present study, an investigation of catalytic activities, western blot and mRNA expression unambiguously demonstrates the prominent expression of the creatine-synthesizing enzymes l-arginine:glycine amidinotransferase and N-guanidinoacetate methyltransferase in sarcoma, Ehrlich ascites carcinoma and Sarcoma 180 cells, w...