OBJECTIVES The study aimed to evaluate the long-term efficacy of microdebrider-assisted inferior turbinoplasty (MAIT) compared to radiofrequency-assisted inferior turbinoplasty (RAIT) for hypertrophic inferior turbinates. STUDY DESIGN Surgical outcomes were evaluated using the visual analogue scale, anterior rhinomanometry, and saccharin test results. METHODS From January 2001 to December 2...

Stress can promote palatable food intake, and consumption of palatable foods may dampen psychological and physiological responses to stress. Here we develop a rat model of daily limited sweetened drink intake to further examine the linkage between consumption of preferred foods and hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress. Adult male rats with free access...

An examination of a large number of samples of sweetened aerated water indicates that saccharin is being extensively used as a sweetening agent in this country although this is not known to the majority of consumers. As saccharin is about 300 to 500 times sweeter than sugar, and the price is not proportionately higher, there is a great likelihood of this synthetic product being used to a larger...

An illness-induced taste aversion was conditioned in rats by pairing saccharin with cyclophosphamide, an immunosuppressive agent. Three days after conditioning, all animals were injected with sheep erythrocytes. Hemagglutinating antibody titers measured 6 days after antigen administration were high in placebo-treated rats. High titers were also observed in nonconditioned animals and in condi...

Taste neophobia refers to a reduction in consumption of a novel taste relative to when it is familiar. To gain more understanding of the neural basis of this phenomenon, the current study examined whether a novel taste (0.5% saccharin) supports a different pattern of c-Fos expression than the same taste when it is familiar. Results revealed that the taste of the novel saccharin solution evoked ...

The present study addressed the relationship between the parameters of saccharin drinking behaviour and locomotor activity in an open field environment and long-term alcohol self-administration. In a 22-day initiation phase, male Wistar rats were presented with increasing concentrations of ethanol (2-8%, v/v) in a choice with water. The rats were then given the choice between water and two etha...

Active avoidance of shock can be influenced by manipulations of the CS made while the subjects are curarized and unable to respond instrumentally. After training dogs to respond to a light to avoid shock, Solomon and Turner (1962) curarized them and presented one tone paired with shock (S + ) and another not paired (S ). The dogs subsequently emitted the instrumental avoidance response to S + a...

A simple, rapid and inexpensive monoparameter flow-through sensor has been developed for the determination of saccharin in low calorie and dietary products. The method is based on the transient adsorption of the sweetener on Sephadex G-25 solid phase packed to a height of 20 mm in the flow cell. The optimal transient retention of the synthetic sweetener, in terms of sensitivity and sampling fre...

A comparison was made of the effects on hunger and food intake of consuming preloads varying in sweetness and energy content. The preloads were a plain (unsweetened) yogurt, and the same yogurt sweetened to equal intensity with saccharin or glucose, or supplemented with starch. This balanced design made it possible to assess the consequences of adding sweetness to food as well as the consequenc...

Studies suggest that improvements in type 2 diabetes (T2D) post- Roux-en-Y gastric bypass (RYGB) surgery are attributable to decreased intestinal glucose absorption capacity mediated by exclusion of sweet taste-sensing pathways in isolated proximal bowel. We probed these pathways in rat models that had undergone RYGB with catheter placement in the biliopancreatic (BP) limb to permit post-RYGB e...