At antipyretic and analgesic doses, salicylate has no antiplatelet or anti-inflammatory effects, unlike typical inhibitors of the prostaglandin H synthases (PGHSs). We demonstrated that salicylate inhibits PGHS-1 and -2 with a potency inversely related to ambient hydroperoxide concentrations. Salicylate inhibition of PGHS-1 was prevented by 12-hydroperoxyeicosatetraenoic acid (12-HPETE). Increa...

WIDE VARIETY OF METHODS are available for the determination of salicylate in body fluids and tissues. These range from the spot test type used at the patients’ bedside to the organic solvent partition methods employed in more exact studies. In recent years, the method of Brodie et al. (1) involving extraction with ethylene chloride has gained widespread acceptance. The method commonly employs 1...

Salicylate inhibition of the secondary antibody response initiated in vitro on day 0 has been studied in cultures of rabbit lymph node fragments. Levels of 1.25 to 1.5 mM (0.20 to 0.24 mg/ml) sodium salicylate present in serum-free medium throughout an 18- or 21-day culture period completely inhibit the secondary response. This inhibition is largely accomplished by the drug's action during the ...

High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs, which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent...

Electrochemical sensing of methyl salicylate, a key plant volatile has been achieved using a gold nanoparticle (AuNP) modified screen printed carbon electrode (SPCE). The electrochemical response of planar gold electrodes, SPCE and AuNP-SPCE in alkaline electrolyte in the presence and absence of methyl salicylate were studied to understand the amperometric response of various electrochemical re...

Salicylate intoxication is a very common problem in everyday clinical practice. We describe a new case of salicylate-induced reversible Fanconi's syndrome in a 28-year-old Cypriot male who ingested 50 g of acetylsalicylic acid with suicidal intent. To our knowledge, this is the second case ever described. It is suggested that clinicians should be aware of this salicylate intoxication-induced co...

Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism for benzene derivatives on metal surfaces, enabling us to selectively tune the...

1. The effects of salicylate on oxidative phosphorylation and respiration were investigated in liver and brain mitochondria, and in sonically prepared mitochondrial fragments. 2. Salicylate was shown to uncouple oxidative phosphorylation in mitochondrial fragments, as well as in intact mitochondria. The effects of salicylate on mitochondria and oxidative phosphorylation resemble those produced ...

Childhood cancers are a broad range of diseases. Research on the chemopreventive potential of non-steroidal anti-inflammatory drugs, such as aspirin (acetylsalicylate) has yet to be fully directed towards childhood cancers. A prima facie hypothesis on salicylate and childhood cancer would therefore be based on several factors. Firstly, salicylate inhibits the production of inflammatory prostagl...

INTRODUCTION The development of tinnitus and/or hearing loss (THL) in patients receiving chronic salicylate therapy has been demonstrated. However, to date, little scientific data validates this relationship in the large single overdose setting. OBJECTIVE To correlate salicylate levels in patients with the subjective complaint of THL, following an acute salicylate overdose. METHODS A retros...