Background: Salivary gland tumors (SGT) are rare lesions with uncertain histopathology. One of the major signaling pathways that participate in the development of several tumors is protein kinase A. In this pathway, glycogen synthase kinase β (GSK3β) and cAMP responsive element binding protein (CREB3) are two genes which are supposed to be down regulated in most human tumors. The expression lev...

Acinic cell adenocarcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of all primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and ACC is usually more frequent in women than men. Previous radiation exposure and familial predisposition are some of the risk factors for ACC. ACCs rarely inv...

Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoi...

Copy number increase (CNI) of ACTN4 has been associated with poor prognosis and metastatic phenotypes in various human carcinomas. To identify a novel prognostic factor for salivary gland carcinoma, we investigated the copy number of ACTN4. We evaluated DNA copy number of ACTN4 in 58 patients with salivary gland carcinoma by using fluorescent in situ hybridization (FISH). CNI of ACTN4 was recog...

Cases of mucoepidermoid carcinoma (MEC) is common among major salivary gland neoplasms, however infrequent cases are reported for this growth over the palatal region. We presented a case 50-year-old gentleman whom with tumour soft palate 3 different histopathological reports. This had history excision right mass on his first presentation which was as pleomorphic adenoma, he recurrence same site...

Intraduct papillomas of the salivary glands are rare solitary tumours. Most of the reported cases have occurred in minor salivary glands. A case which occurred in the parotid gland is reported. Fine needle aspiration was performed on this tumour, and the cytological appearances of the aspirate were suggestive of an adenoid cystic carcinoma. This is an important potential diagnostic pitfall whic...

Background: Salivary gland tumors are relatively uncommon. It accounts for < 2% of all human neoplasms. They pose considerable clinical management challenges because of their confounding histological and behavioral diversity as well as their proximity to important head and neck structures. The present study was conducted to account different salivary gland tumors among different population. Mat...

introduction: her2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. the purpose of this study was to determine the salivary levels and tissue expression of her2/neu in patients with head and neck squamous cell carcinoma (hnscc) and their correlation with clinicopathologic parameters.   materials and methods: enzyme-linked immunoso...

UNLABELLED Salivary gland tumors constitute a highly heterogeneous histopathologic group. There are few epidemiological studies of large series of benign and malignant salivary gland tumors in Brazil. MATERIAL AND METHODS Hospital records of 124 patients with salivary gland tumors diagnosed from January 1993 to December 1999 were reviewed. The patients were analyzed according to gender, age, ...

ABSTRACT Introduction: Salivary gland tumors are rare malignant neoplasms, with a higher incidence in the parotid gland. Despite their low incidence, possible complications derived from them can lead to high comorbidity patients. Methods: We conducted retrospective, observational and descriptive study of 105 patients diagnosed neoplasms salivary glands at Hospital Universitario La Paz. 102 corr...