Ayşe Sayılı*1, MD, Ozgur Tosun2, Nazan Cobanoglu1, Nerin Bahceciler Onder1, Fusun Baba3, Salih Kavukcu1 1Department of Pediatrics, 2Department of Radiology, 3Department of Pathology, Near East University Faculty of Medicine, Turkish Republic of Northern Cyprus Received: Sep 11, 2013; Accepted: Apr 23, 2014; First Online Available: Aug 15, 2014 Dear Editor, Referring to synovitis, acne, pustulos...

The authors report a case of SAPHO Syndrome, in pediatric age, with a dermatological focus. This entity should be considered in patients who have pain in the anterior chest wall or other musculoskeletal symptoms, accompanied by palmoplantar pustulosis and acne fulminans. The specific cutaneous manifestations, diagnosis and the treatment will be presented.

The acronym of SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) combines a cluster of cutaneous and musculoskeletal manifestations, such as hyperostosis of bones of the anterior chest wall associated with acne fulminans and hidradenitis suppurativa. There are no validated diagnostic criteria in children. Nonsteroidal anti-inflammatory drugs are not always sufficient, and ...

Background Chronic nonbacterial osteomyelitis (CNO) is a rare bone disease characterized by sterile inflammation and locally increased turnover. CNO that occurs in the rheumatic spectrum of synovitis, acne, pustulosis, hyperostosis osteitis referred to as SAPHO syndrome [1, 2]. To date, there are no objective biomarkers for monitoring activity. Recommended imaging tools like technetium radiolab...