Structure-activity relationship (SAR) is one of the foundational principles of biomolecular activity and states that similar molecules have similar biological activity. This work is focused on the utilization of enzymatic reactions in order to augment ligands with small apolar substituents. These modified molecules will then be employed for establishing the SAR of a ligand series. For this purp...

A structure-activity relationship (SAR) study on 5-substituted oxazolidinones as an antibacterial agent is described. The oxazolidinones, of which 5-acetylaminomethyl moiety was converted into other functions, were prepared and evaluated for antibacterial activity. Elongation of the methylene chain (8) and conversion of the acetamido moiety into guanidino moiety (12) decreased the antibacterial...

We describe the 'Structure-Activity Relationship (SAR) Matrix' (SARM) methodology that is based upon a special two-step application of the matched molecular pair (MMP) formalism. The SARM method has originally been designed for the extraction, organization, and visualization of compound series and associated SAR information from compound data sets. It has been further developed and adapted for ...

The aporphine alkaloids are known to have affinities as the dopaminergic, adrenergic and serotonergic receptor system. Hence the aporphine template can be considered as a privileged scaffold for the design of selective monopotent as well as multi-potent Central Nervous System (CNS) ligands. This review attempts to summarize the recent Structure Activity Relationship (SAR) studies of aporphine a...

One of the earliest accomplishments of theoretical ecology was the discovery of a relationship between the number of species (of plants, birds, beetles, or whatever) on a given island and the area of that island (1). For example, a 10-fold increase in island area approximately doubles the number of species. This species-area relationship (SAR) is often used by conservation biologists to assess ...

This paper proposes a statistical generalized species-area model (GSAM) to represent various patterns of species-area relationship (SAR), which is one of the fundamental patterns in ecology. The approach enables the generalization of many preliminary models, as power-curve model, which is commonly used to mathematically describe the SAR. The GSAM is applied to simulated data set of species dive...

This work is concerned with generating the digital elevation models (DEMs) from the SAR images of the region of interest using multiple sensor arrays that are fixed on the distributed satellites. We present an exact estimate of the unwrapped phase and the relationship between the unwrapped phase and the terrain height. The optimum scheme that jointly processes the signals from all sensors is ba...

Plant active metabolites are under intensive examinations around the world to supplement the drugs with minimal side effects. Thus, there is vast potential to explore the possible medicine from the plant sources. Cardiac glycosides are a unique group of secondary metabolites that they are considered one of the most useful drugs in therapeutics. In this review, cardiac glycosides and their analo...

STRUCTURE-ACTIVITY RELATIONSHIP MODEL FOR ESTROGEN RECEPTOR LIGANDS Huihui Wu November 29,2011 Xenoestrogens are spread throughout the environment affecting our daily lives and may produce potential toxic effects on human health. The purpose of this study was to develop a mechanistically reliable model capable of identifying xenoestrogens. Our hypothesis was that there are identifiable structur...

Recent interest in dual-pol SAR systems has lead to a novel approach to dual-pol SAR, the so-called compact polarimetric imaging mode. The original idea, presented by Souyris et al. [1], employed a SAR system transmitting a linearly polarized wave rotated by 45° with respect to the orientation of the vertical (V) and horizontal (H) receive antennas. One then constructed pseudo quad-pol data fro...