PURPOSE Gallbladder sarcomatoid carcinoma is a rare cancer with no clinical standard treatment. With the rapid development of next generation sequencing, it has been able to provide reasonable treatment options for patients based on genetic variations. However, most cancer drugs are not approval for gallbladder sarcomatoid carcinoma indications. The correlation between drug response and a genet...

INTRODUCTION We report the case of a 62-year-old woman diagnosed with sarcomatoid renal cell carcinoma. CASE PRESENTATION A 62-year-old Asian woman presented with macroscopic hematuria. A histological and immunohistochemical study of a tumor biopsy specimen led to a suspected diagnosis of sarcomatoid renal cell carcinoma. She underwent surgical tumor resection that included her left kidney. A...

Objective: To explore the clinical, pathology, and prognosis of sarcomatoid carcinoma of the renal pelvis. Methods: A case of the diagnosis and treatment of sarcomatoid carcinoma of the renal pelvis in our hospital were retrospectively analyzed. Articles were searched from the full-text databases, such as NCBI and PUBMED, the dates of clinical and pathology was collected from the satisfied arti...

PURPOSE Activation of MET oncogene as the result of amplification or activation mutation represents an emerging molecular target for cancer treatment. We comprehensively studied MET alterations and the clinicopathologic correlations in a large cohort of treatment-naïve non-small cell lung carcinoma (NSCLC). EXPERIMENTAL DESIGN Six hundred eighty-seven NSCLCs were tested for MET exon 14 splici...

Sarcomatoid (spindle cell) carcinoma of the pancreas is a rare, high-grade epithelial malignancy composed predominantly or exclusively of spindle cells demonstrating evidence of epithelial derivation, but no features indicative of a specific line of mesenchymal differentiation. The current study presents the case of an 85-year-old Caucasian male with a tumor mass in the body of the pancreas. Th...

Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. Sarcomatoid renal c...

Cervical sarcomatoid squamous cell carcinoma (SSCC) is an extremely rare malignancy. We report the case of a young woman with cervical SSCC who experienced peri-menopausal syndrome following treatment, and present our evaluation of the considerations relating to hormone replacement therapy (HRT) in this case. A 24-yearold Chinese woman with SSCC underwent radical hysterectomy with bilateral sal...

Sarcomatoid renal cell carcinoma (sRCC) is an aggressive variant of renal cell carcinoma (RCC) that has a significantly lower overall survival. Even after prompt surgical extirpation, this histologic variant progresses rapidly. We present a case of an early recurrence and rapid progression of sRCC despite successful radical resection.

Cholangiocarcinoma (CC) is an adenocarcinoma arising from epithelial cells of varying locations within the biliary tree, and is the second most common primary liver tumor, accounting for approximately 10-15% of all hepatobiliary malignancies. This disease has a high prevalence in Southeast and Eastern Asia, including Korea; during the period 2003-2005, the age-standardized incidence rates of in...

Objective: To explore the clinical, pathology, and prognosis of sarcomatoid carcinoma of the renal pelvis. Methods: A case of the diagnosis and treatment of sarcomatoid carcinoma of the renal pelvis in our hospital were retrospectively analyzed. Articles were searched from the full-text databases, such as NCBI and PUBMED, the dates of clinical and pathology was collected from the satisfied arti...