Within PrefHer (NCT01401166), patients and healthcare professionals (HCPs) preferred subcutaneous (SC) over intravenous (IV) trastuzumab. We undertook a prospective, observational time and motion study to quantify patients' time in infusion chairs and active HCP time in PrefHer. Patients with HER2-positive early breast cancer received four adjuvant cycles of SC trastuzumab (600 mg fixed dose vi...

UNLABELLED P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham's chorea (SC) patients. PURPOSE To assess cognitive impairment with P300 ERPs. METHOD Seventeen patients with SC and 20 unaffected healthy children were included. Stanford-Binet test was used for psychometric assessment, and odd-ball paradigm was used for au...

Sesamin, a major lignan in sesame seeds and oil, has been known to lower blood pressure in several types of experimental hypertensive animals. A recent study demonstrated that sesamin metabolites had in vitro radical-scavenging activities. Thus, we determined whether the antioxidative effect of sesamin metabolites modulate the vascular tone and contribute to the in vivo antihypertensive effect ...

The outermost layer of the skin, the stratum corneum (SC), is a lipid-protein membrane that experiences considerable osmotic stress from a dry and cold climate. The natural moisturizing factor (NMF) comprises small and polar substances, which like osmolytes can protect living systems from osmotic stress. NMF is commonly claimed to increase the water content in the SC and thereby protect the ski...

A series of criteria such as morphological metrics, pathology, age structure, sex ratios, relative proportions, archaeological phenomena, diet analysis, and DNA studies are established for identifying the origins domestic animals in ancient China a scientific way. Using these criteria, it is that earliest dog has been found southern Hebei Province (ca. 10,000 BP), pig Henan 9000 BP...

This study proposes a bilevel programming model in which the supply chain (SC) director determines optimal performance levels of corporate social responsibility (CSR) and compensation for all SC actors, thus maximizing total SC profits. Given the fixed CSR performance levels, the equilibrium product flows are determined in the lower-level model, in which the profit-maximizing behavior of the in...

Modulation of neural responses is frequently observed in the superior colliculus (SC), a retinorecipient midbrain structure that controls orienting and the localization of attention. Although behavioral contingencies that influence SC responses are well documented, the neural pathways and molecular mechanisms responsible for this modulation are not completely understood. Here, we illustrate a d...