PURPOSE To characterize patients with ocular surface drying and a diagnosis of keratoconjunctivitis sicca (KCS). METHODS Patients with a prior diagnosis of KCS and symptoms of dryness or foreign-body sensation who also had vital staining of the interpalpebral fissure ocular surface in the absence of lid and ocular surface inflammation were entered into the study along with normal controls. Pa...

The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS). Twenty five dogs with KCS treated with a topical carbomer (CA)-based tear replacement gel were moved to treatment with a hyaluronic acid (HA)-containing tear replacement eye drop. Dogs were subject to a fu...

BACKGROUD This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery. METHODS A total of 149 eyes (149 patients) diagnosed with age-related cataract, age 69.19 ± 9.74 years, were enrolled in this prospective, parallel-design, continuous, randomised controlled study. Patients were randomly as...

OBJECTIVE The international criteria for primary Sjögren's Syndrome (SS I) diagnosis (Vitali et al. 2002) include the Schirmer test I and vital dye staining as tests for ocular surface involvement, but diagnosis can be reached also when the item for ocular signs is not satisfied. The purpose of our study was to evaluate the ocular surface in patients with Sjögren's Syndrome, non-Sjögren's autoi...

PURPOSE To assess the efficacy of dietary consumption of omega-3 fatty acids (O3FAs) on dry eye symptoms, Schirmer test, tear film break up time (TBUT) and conjunctival impression cytology (CIC) in patients with computer vision syndrome. SETTING AND DESIGN Interventional, randomized, double blind, multi-centric study. METHODS Four hundred and seventy eight symptomatic patients using compute...

To study the quantitative effects of megavoltage external beam irradiation in a D-shaped field in patients with retinoblastoma, biomicroscopy was performed in 61 patients and tear function tests (Schirmer-lactoferrin and lysozyme tests) on 45 eyes in 34 irradiated patients. The results were compared with those obtained in 25 non-irradiated control eyes. The Schirmer test was significantly dimin...

BACKGROUND To determine the diagnostic performance of tear osmolarity in diagnosis of dry eye disease by using tear lab osmolarity system in people with type 2 diabetes, and to compare it with common diagnostic tests already available in clinical practice. METHODS Two hundreds forty three people with type 2 diabetes were included. Tear osmolarity was measured with the tear osmolarity system. ...

BACKGROUND Diabetes-related eye disease is due in part to oxidative stress. Gamma-glutamyl transpeptidase (GGT) is a γ-glutamyl cycle enzyme that protects against oxidative stress via glutathione recapture. This study investigates corneal and Schirmer tears GGT activity in diabetic and non-diabetic adults aged 50 to 83 years old. METHODS GGT activity was determined by colorimetric assay on 50...