Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae (lgl) has an essential function in establi...

Human schistosomiasis, also known as bilharziasis is a complex of acute and chronic parasitic infections caused by mammalian blood flukes belonging to the genus Schistosoma. The disease is endemic in 74 countries with an estimated 200 million people infected, of whom 120 million are symptomatic and 20 million have severe disease. Six hundred million people are at risk of infection [1]. The infe...

Central nervous system (CNS) involvement may occur in chronic schistosomiasis. It can be produced by any Schistosome species but happens most frequently in chronic Schistosoma japonicum infection. CNS involvement by S. mansoni is relatively rare but it may occur by embolization of eggs or ectopic migration of adult worms. A case of cerebral schistosomiasis caused by S. mansoni in a 40-year-old ...

Schistosomiasis japonica is a serious parasitic disease and a major health risk for more than 60 million people living in the tropical and subtropical zones of south China. The disease is a zoonosis and its cause, the parasitic trematode Schistosoma japonicum, has a range of mammalian reservoirs, making control efforts difficult. Current control programs are heavily based on community chemother...

The pathological outcomes of schistosomiasis are largely dependent on the molecular and cellular mechanisms of the host immune response. In this study, we investigated the contribution of variations in host gene expression to the contrasting hepatic pathology observed between two inbred mouse strains following Schistosoma japonicum infection. Whole genome microarray analysis was employed in con...

BACKGROUND Schistosomiasis japonica remains a real threat to public health in China. The currently used immunodiagnostic assays are sensitive and have a certain degree of specificity, however, they all use complex crude antigens, are based on detection of schistosome-specific antibodies, and have been shown to cross-react with other parasitic diseases. Therefore, these assays cannot be used to ...

Schistomiasis is a disease caused by digenetic trematodes that belong to the family Schistosomatoidae. Five species of Schistosomes are involved in human infection. The three principal agents are Schistosoma mansoni and S. japonicum which are responsible for intestinal schistosomiasis and S. haematobium, the aetiologic agent of urinary schistosomiasis. The other two species responsible for inte...

central nervous system involvement arising from schistosomiasis is uncommon. it may be produced most fre­quently by schistosoma japonicum infection, but reports of s. mansoni presenting as an intracerebral mass lesion are particularly rare. the authors describe the case of a 35-year-old woman with a 3-month history of partial epilep­tic seizures and head­aches. she immigrated to egypt 4 years a...

Schistosomiasis japonica remains a significant public-health problem in China. This study evaluated cost-effectiveness of a comprehensive schistosomiasis control program (2003-2006). The comprehensive control program was implemented in Zhangjia and Jianwu (cases); while standard interventions continued in Koutou and Xiajia (controls). Incurred costs were documented and the schistosomiasis compr...

BACKGROUND Trematodes belonging to the genus Schistosoma cause schistosomiasis. The relationship between schistosomes and their intermediate hosts varies among snails. This study investigated the effects of S. japonicum on its snail host, Oncomelania hupensis, and cercarial release rythmicity of S. japonicum and the effects of light on it. METHODS Seven groups of O. hupensis (n = 40 each) wer...