Schizoaffective disorder (SA) is distinguished from schizophrenia (SZ) based on the presence of prominent mood symptoms over the illness course. Despite this clinical distinction, SA and SZ patients are often combined in research studies, in part because data supporting a distinct pathophysiological boundary between the disorders are lacking. Indeed, few studies have addressed whether neurobiol...

Affective psychoses are a group of severe psychiatric disorders, including schizoaffective disorder and bipolar I disorder, together affecting ∼1% of the population. Despite their high heritability, the molecular genetics and neurobiology of affective psychosis remain largely elusive. Here, we describe the identification of a structural genetic variant segregating with affective psychosis in a ...

BACKGROUND Hallucinations are a major aspect of psychosis and a diagnostic feature of both psychotic and mood disorders. However, the field lacks information regarding the long-term course of hallucinations in these disorders. Our goals were to determine the percentage of patients with hallucinations and the relationship between hallucinations and recovery, and work attainment. Method The prese...

The suggestion of a relationship between creativity and mental disorder has existed for centuries, and has been advocated by many psychological researchers. The present analysis offers a consideration of the nature of mental disorder present in Brian Wilson, an individual recognised as one of the most creative figures in 20th century popular music. Using converging biographical evidence, and th...

Patients: 309 people, admitted for the first or second time, presenting with schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, or psychosis (DSMIV criteria). Participants had psychotic symptoms, not caused by substance misuse, for .4 weeks and scored 4 or more on the Positive and Negative Syndrome Scale (PANSS). People detained in hospital under the Mental...

An increased prevalence of type 2 diabetes (T2D) in schizophrenia (SCZ) patients has been observed. Exposure to antipsychotics (APs) has been shown to induce metabolic dysregulation in some patients but not all treated patients. We hypothesized that important candidate genes for T2D may increase risk for T2D in African-American patients with SCZ or schizoaffective disorder. The PAARTNERS study ...

July 01, 2006 | Bipolar Disorder [1], Personality Disorders [2], Schizoaffective [3], Schizophrenia [4], Borderline Personality [5], Antisocial Personality Disorder [6], Mood Disorders [7], Bipolar II Disorder [8], Mania [9], Forensic Psychiatry [10], Neuropsychiatry [11], Addiction [12], Alcohol Abuse [13], Dysthymia [14] By Silvio Bellino, MD [15], Erika Paradiso, MD [16], and Filippo Bogetto...