BACKGROUND Neuropathic pain caused by peripheral nerve injury is a chronic disorder that represents a significant clinical challenge because the pathological mechanisms have not been fully elucidated. Several studies have suggested the involvement of various sodium channels, including tetrodotoxin-resistant NaV1.8, in affected dorsal root ganglion (DRG) neurons. We have hypothesized that altere...

objective: to assess the neuroprotective effects of local administration of 17- beta- estradiol on nerve regeneration. methods: sixty female wistar rats were overiectomized and divided into four experimental groups (n = 15), randomly: in autograft group a segment of sciatic nerve was transected and re-implanted reversely. in sham-surgery group sciatic nerve was exposed and manipulated. in trans...

OBJECTIVES To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection. MATERIALS AND METHODS Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was perfor...

Sciatica means pain along sciatic nerve distribution. The most important symptoms are radiating leg pain and related disabilities. Patients are commonly treated in primary care but a small proportion is referred to secondary care and may eventually need surgery. Many synonyms for sciatica appear in the literature, such as lumbosacral radicular syndrome, ischias, nerve root pain, and nerve root ...

Objective- Comprehensive functional, histomorphometrical and immunohistochemical assessment of sciatic nerve regeneration through an inside-out vein graft in rat. Design- Experimental in vivo study. Animals- Fifty- four healthy male White Albino rats. Procedures- The rats were divided into three experimental groups (n=18), randomly: Sham-operation (NC), Transected control (TC) and Inside-out ve...

Studies have confirmed that bone marrow-derived mesenchymal stem cells (MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs (BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs (ADSCs) have phenotypic and gene expressio...

introduction: it has been demonstrated that the adrenal medullary transplants into the spinal subarachnoid space can alleviate neuropathic pain behaviors. the aim of the present study was to test the possibility that histological changes of the sciatic nerve in a neuropathic model as well as sensory dysfunction are repaired by adrenal medullary transplantation. material and methods: left sciati...

Inflammatory cells play a critical role during nerve regeneration following peripheral nerve injury. In this study, we investigated immune responses in rat sciatic nerve after injury. Wistar rats were randomly divided into the sciatic nerve injury (model) group and control group. The right sciatic nerve of rats in the model group was transected and sutured end-to-end. Our results showed that ra...

objective(s):diabetic neuropathy (dn) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. the aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, win 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. materials and methods: dia...

Background: Peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. Objectives: The purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (ESM) guidance channel with autograft. Materials and Methods: Thirty adult male rats were divided into th...