PURPOSE We tested the hypothesis that the variation of peripapillary scleral structural stiffness with age is different in donors of European (ED) and African (AD) descent. METHODS Posterior scleral shells from normal eyes from donors of European (n = 20 pairs; previously reported) and African (n = 9 pairs) descent aged 0 and 90 years old were inflation tested within 48 hours post mortem. Scl...

Residual deformations strongly influence the local biomechanical environment in a number of connective tissues. The sclera is known to be biomechanically important in healthy and diseased eyes, such as in glaucoma. Here, we study the residual deformations of the sclera, as well as the adjacent choroid and retina. Using freshly harvested porcine eyes, we developed two approaches of quantifying r...

introduction in order to treat uveal melanoma , first, radioactive seeds are laid on a silicone- made substance which is called silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. the dose gradient within the tumor and healthy tissues can be varied due to changing the silastic thickness between scler...

Purpose: To update the accommodation mechanisms and propose a dual-wavelength, dual-function laser system for presbyopia glaucoma treatments.
 Study Design: Laser sclera softening (LSS) increased of presbyopic eyes.
 Place Duration Study: New Taipei City, Taiwan, between Jan., 2023 Feb., 2023.
 Methodology: Accommodation gain (AG) can be improved by: (i) thermal shrinkage scleral...

With this investigation, the anatomy of bulbus oculi was studied in 12 Akkaraman sheep. The oculi’s specific morphological features breed were introduced study. In border cornea and scle-ra, limbus ended at point where it entered under sclera. eyes examined, existence rima cornealis sclera not observed. Based on observations made, center thinner com-parison with its periphery. sheep, determined...

PURPOSE One of the current limitations in developing novel glaucoma drugs that target the trabecular meshwork (TM) is the induced corneal toxicity from eyedrop formulations. To avoid the corneal toxicity, an alternative approach would be to deliver TM drugs through the sclera. To this end, we quantified ex vivo diffusion coefficient of a potential TM drug, ethacrynic acid (ECA), and investigate...

PURPOSE The proteoglycans synthesized and accumulated within the adult human sclera (aged 50 to 80 years) were identified by their size, glycosaminoglycan side chains, and core proteins in an effort to characterize the proteoglycan content of the human sclera. METHODS Sclerae, unlabeled, or radiolabeled in organ culture with 35SO4 or 3H-proline, were extracted in 4M guanidine-HCl and separate...

PURPOSE It is proposed that the sclera is a metabolically active and pharmacologically responsive tissue. These studies were undertaken to determine whether prostaglandin exposure can enhance scleral permeability to high-molecular-weight substances. METHODS Topical prostaglandin F2 alpha (PGF2 alpha) was administered to monkeys to determine if this altered the amount of scleral matrix metallo...

come clinically visible, resulting in the blue appearance of the sclera. We report the treatment of rhegmatogenous retinal detachment in 4 eyes of 3 patients with OI. Scleral buckling surgery, pneumatic retinopexy, and primary vitrectomy are the standards for repair of uncomplicated rhegmatogenous retinal detachments. In patients with OI, however, the thin sclera provides an increased risk of s...