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The reciprocal hemizygosity test is a straightforward genetic test that can positively identify genes that have evolved to contribute to a phenotypic difference between strains or between species. The test involves a comparison between hybrids that are genetically identical throughout the genome except at the test locus, which is rendered hemizygous for alternative alleles from the two parental...

Risk assessment is an essential component of genetic counseling and testing, and Bayesian analysis plays a central role in genetic risk assessment. Bayesian analysis allows calculation of the probability of a particular hypothesis, either disease or carrier status, based on family information and/or genetic test results. Genetic risk should be assessed as accurately as possible for family decis...

Advances in genetics and genetic testing promise to catalyze a fundamental change in the practice of medicine. Psychologists have much to offer as psychotherapists, researchers, educators, and policymakers to a society heavily influenced by the genetic revolution. To make the most of new opportunities available to mental health professionals in genetics, psychologists must know basic genetic pr...

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James Liley, John A Todd, and Chris Wallace JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, CB2 0SP, UK MRC Biostatistics Unit, Institute of Public ...

The recent boom of direct-to-consumer (DTC) genetic tests, aimed at measuring children's athletic potential, is the latest wave in the 'pre-professionalization' of children that has characterized, especially but not exclusively, the USA in the last 15 years or so. In this paper, I analyse the use of DTC genetic tests, sometimes coupled with more traditional methods of 'talent scouting', to asse...

The field of behavioral genetics has engendered a host of moral and social concerns virtually since its inception. The policy implications of a genetic basis for behaviors are widespread and extend beyond the clinic to the socially important realms of education, criminal justice, childbearing, and child rearing. The development of new techniques and analytic approaches, including whole-genome s...

W e thank the authors for reporting an unexpected clustering of Caucasian patients with the Val142Ile (more commonly known as Val122Ile) mutation. These interesting findings further emphasize the importance of genetic counseling and clinical genetic testing in patients with TTR cardiac amyloidosis.commercial use, distribution, and reproduction in any medium, provided the original work is proper...

LEARNING OBJECTIVES After completing this IBD LIVE-CME activity, physicians should be better able to: 1. Identify monogenic causes of early onset IBD. 2. Know when genetic testing might benefit the management of select IBD patients. 3. Be aware of potential clinical, endoscopic and histologic findings in early onset IBD. 4. Understand the pathophysiology and potential clinical course of IBD in ...