Production of baicalein, baicalin and wogonin by liquid culture of Scutellaria baicalensis cells derived from the plant root was studied. The maximum production obtained were 119 mg/L of baicalein at two week, 1372 mg/L of baicalin at eight week, and 14 mg/L of wogonin at two week. In addition, the production of baicalin was drastically increased to 1000 mg/L level at 3-week culture, and the ex...

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines I-L (1-4), were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were established on the basis of detailed spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 color...

The genus Scutellaria L., Lamiaceae family, Scutellarioideae sub-family is known as the most important medicinal plant in world. This research aimed to investigate flavonoid content of seven species from center, southwest, and west Iran. Via thin layer column chromatography, was extracted leaves then purified. To screen compositions, a chromatographic method applied by liquid chromatography mas...

Public and academic discourses about the Polar regions typically focus on the so-called natural environment. While, these discourses and inquiries continue to be relevant, the current article asks the question how to conceptualize the on-going industrial and infrastructural build-up of the Arctic. Acknowledging that the "built environment" is not an invention of modernity, the article neverthel...

In a systematic investigation for new antibiotics it was observed by one of us (A. K.) that the crude culture filtrate of Aspergillus luteo-virescens was found to be antagonistic to gram-positive and gram-negative bacteria. In the chemical studies conducted by two of us (W. K., R. K.) it was noted that an antibiotic substance crystallized out in large amounts from this crude culture upon standi...

A 15 kDa ribonuclease (RNase) was purified from dried fruiting bodies of the wild edible mushroom Armillaria luteo-virens. The simple 4-step purification protocol involved ion-exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on SP-Sepharose and a final gel filtration by FPLC on Superdex-75. The RNase was unadsorbed on Affi-gel ...

Four new neo-clerodane diterpenoids, scutebarbatines W-Z (1-4), were isolated from the ethanol extract of Scutellaria barbata (Labiatae), and their structures were elucidated on the basis of extensive spectroscopic studies. In addition, the proposed structures of at least seven 13-spiro subtype neo-clerodanes: scutehenanine B (5), scutebarbatine G (6), 6-O-nicotinoylscutebarbatine G (7), barbat...

In the present study, we investigated the in vitro and in vivo antitumor effects of crude extract of Scutellaria Barbate (CE-SB) on mouse hepatoma H22 cells. The MTT assay was used to determine the growth inhibition of H22 cells in vitro. The in vivo therapeutic effects of CE-SB were determined using H22 tumor bearing mice. Besides, the body weight, tumor weight, thymus index and spleen index o...