BACKGROUND Multipotent mesenchymal stem cells (MSCs) are used clinically in regenerative medicine. Our previous report showed systemically injected MSCs improved peri-implant sealing and accelerated tissue healing. However, the risks of systemic MSC administration, including lung embolism, must be considered; therefore, their local application must be assessed for clinical safety and efficacy. ...

BACKGROUND Suture hole bleeding from synthetic grafts presents a hemostatic challenge. The designs of many vascular sealants are not optimal (non-adherence to wet surfaces, excessive swelling, inflexible). PreveLeak™ (formerly ArterX ((®)) ) is a polyaldehyde-bovine serum albumin-based sealant whose efficacy, safety, and performance were evaluated in this first-in-human study. MATERIALS AND M...

In order to discuss the impact of land consumption, it is first necessary to localize and quantify the extent of sealed surfaces. Since 2010, the monitoring of land use structures and developments in Germany has been provided by the Monitor of Settlement and Open Space Development at the Leibniz Institute of Ecological Urban and Regional Development (IÖR; IÖR Monitor), a scientific service oper...

Multilayered hard coatings with a CrN matrix and an Al2O3, TiO2, or nanolaminate-Al2O3/TiO2 sealing layer were designed by a hybrid deposition process combined with physical vapor deposition (PVD) and atomic layer deposition (ALD). The strategy was to utilize ALD thin films as pinhole-free barriers to seal the intrinsic defects to protect the CrN matrix. The influences of the different sealing ...

Longitudinal and circular pressure sealing closures were designed and developed for full pressure protective assemblies from a design concept provided by the Aerospace Medical Research Laboratories, invention disclosure number 66/588. This study consisted of (1) designing pressure closure devices, (2) selecting suitable materials for the fabrication of the sealing closure parts and the cylinder...

OBJECTIVE To evaluate the efficiency of a hydrogel adherent ocular bandage for sealing of scleral tunnel incisions in human eye globes. METHODS A 4-mm scleral tunnel incision was made in each of 10 globes and bursting pressure was measured using the Seidel test to check for wound leakage. Globes were sealed using either two interrupted 10-0 nylon sutures (n = 5) or an adherent ocular bandage...

The sealing of the root canal system is of fundamental importance for successful endodontic treatment. To obtain an adequate apical seal, many factors must be considered such as the presence of smear layer and the sealer applied. After canal preparation, this layer must be removed because it prevents close contact between the dentinal walls and the sealing material. The goal of this study was t...