Background: Cutaneous appendageal tumours can arise from either the eccrine, apocrine, hair follicles or the sebaceous glands. Majority of the tumours are benign. Final diagnosis requires a good clinical as well as histpathological correlation. The aim of the present study was to assess the clinicopathological characteristic of these tumours. Materials & Methods: The present study was a retro-p...

Distinct stem cell populations are present in the skin that comprises the epidermis and the pilosebaceous unit (hair follicle and sebaceous gland) (Clayton et al., 2007; Mascre et al., 2012). Recent studies have highlighted the strong heterogeneity and compartmentalization of stem cell niches in the skin (Jaks et al., 2010; Page et al., 2013). During telogen (resting phase), hair follicle stem ...

Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous diffe...

Sebaceous carcinoma (SC) is a neoplasm derived from the adnexal epithelium of the sebaceous glands, and most studies on this neoplasm have been conducted in Caucasians. We retrospectively reviewed the records of 29 patients with SC (16 extraocular and 13 ocular lesions) who were diagnosed from 2001 to 2014 to analyze the clinical and histopathological features of SC in the Korean population. Si...

Cutaneous appendageal tumors are a large diverse group of tumors that are commonly classified according to their state of appendageal differentiationeccrine, apocrine, follicular and sebaceous. Most appendageal tumors are relatively uncommonly encountered in routine clinical practice. Though some of the appendageal tumors (e.g. syringoma, nevus sebaceous) can be diagnosed clinically with ease b...

The mechanisms by which mammalian epidermal stem cells cease to proliferate and embark upon terminal differentiation are still poorly understood. By conditionally ablating two highly expressed transcription factors, AP-2alpha and AP-2gamma, we unmasked functional redundancies and discovered an essential role for AP-2s in the process. In vivo and in vitro, AP-2 deficiency is accompanied by surpr...