BACKGROUND Pharmacological and postmortem investigations suggest that patients with major depressive disorder have alterations in function or density of brain serotonin1A (5-HT1A) receptors. The aim of the present study was to use positron emission tomography with the selective 5-HT1A receptor antagonist [11C]WAY-100635 to measure 5-HT1A receptor binding in depressed patients before and during ...

Botulinum neurotoxins and tetanus are the strongest known toxins that cause neuroparalytic syndromes in botulism tetanus. This review aimed to systematize scientific data on structures mechanism of actions botulinum neurotoxins. proteins containing functional domains responsible for receptor binding, transmembrane translocation, proteolytic cleavage required exocytosis synaptic vesicles release...

Antibodies were raised against a newly synthesized analog (CP57,609) of the alpha 1-selective antagonist prazosin, and against the alpha 2-selective antagonist, yohimbine, by immunization of rabbits with antigens prepared by covalent linkage of these ligands to albumin. Competitive inhibition of [3H]prazosin binding to anti-CP57,609 antiserum by a variety of unlabeled ligands revealed a spectru...

Imidafenacin is a potent and selective antagonist of M1 and M3 muscarinic receptors that is safe, efficacious, and well tolerated for controlling the symptoms of overactive bladder (OAB). However, the precise mechanisms responsible for the bladder-selective pharmacological effects of this agent remain unclear. The in vivo pharmacologic effects of imidafenacin result from receptor occupancy. The...

Orbital-selective phenomena in mutliorbital systems have received much attention due to their uniqueness as well possible connections other phenomena. As orbital-selectiveness is mostly related the crystal structure, finding a new control parameter than structure would be of significant importance. Here we report discovery an orbital-selective doping effect ${\mathrm{Sr}}_{2}{\mathrm{Ru}}_{1\en...

Positively charged naturally occurring or engineered peptide nanofibrils (PNF) are effective enhancers of lentiviral and retroviral transduction, an often rate-limiting step in gene transfer therapy approaches. These polycationic PNF thought to bridge the electrostatic repulsions between negatively membranes virions cells, thereby enhancing virion attachment infection target cells. Here, we ana...