Social anxiety disorder is an anxiety disorder in which a person has an excessive and unreasonable fear of social situations. Social anxiety and self-consciousness arise from a fear of being closely watched and criticized by others. Clinical observation also suggests that some persons with social anxiety disorder may experience intense anger at others upon perceived negative evaluation or when ...

objective(s):  infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. recombinant dna technology allows expression of the l1 major capsid protein of hpv in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (vlp). vlps are non-infectious, highly immunogenic and can elicit neutralizing a...

Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...

materials and methods the expression of gp73 was investigated in 88 cancerous and self-control non-cancerous tissues using tissue microarrays with immunohisto- chemistry and was confirmed by western blotting. circulating gp73 levels were detected in the sera of 281 patients with liver diseases using enzyme-linked immunosorbent assay. results the levels of circulating gp73 expression in the hcc ...

objectives: long non-coding rnas (lncrnas), a vast class of recently discovered non-coding genes in the human genome, have been implicated in the regulation of several biological processes, including the maintenance of stem cell pluripotency and neurogenesis. new evidences have emerged that some long incrnas act as enhancers for their neighboring genes. oct4, also known as pou5f1 and oct3/4, fu...

abstract regeneration is a biological phenomenon, which takes place via two main mechanisms: first, dedifferentiation of mature cells followed by their differentiation into functional new cells and second, activation of endogenous somatic stem cells for regeneration of damaged or lost tissues. one of the best examples of healing process in mammals is the regeneration of damaged pinna in rabbits...

Objective(s)The key transcriptional regulator Oct4 is one of the self-renewal and differentiation-related factors in cancer stem cells, where it maintains "stemness" state. Cancer stem cells have been identified in a variety of solid malignancies. They are a small population of tumor cells with stem cell characteristics, which are a likely cause of relapse in cancer patients. Due to high incide...

Abstract
 Objectives: The main purpose of nursing education is to make students self-confident, healthy professionals who can solve their problems.This study aimed the examination mediating roles emotional expression and self-esteem in relationship between social problem solving psychological well-being students. 
 Materials Methods: was conducted an analytical cross-sectional design....