Three newly synthesized copper complexes: [Cu(PLSC)Cl2](1), [Cu(PLSC)(H2O)(SO4)]2.3H2O(2), [Cu2(PLSC)2(NCS)2] (NCS)2 (3) with pyridoxal semicarbazone (PLSC), as ligand, after being subjected to biological tests, showed anticancer activity. As ligand PLSC is biologically active, the results of biological activity are as expected. Specifically, an activity was demonstrated in breast cancer cells ...

A spectrophotometric method has been developed for the determination of Mo(VI) using Acetophenone 2’,5’dihydroxy, semicarbazone as an extractive reagent .The reagent form a colored complex which has been quantitatively extracted into n-Butanol at pH 2.0. The method obeys Beer’s law over a range of 1 to 10 ppm. The molar absorptivity is 7150.83 L molcm and Sandell’s sensitivity is 0.00781 μg cm ...

A series of 4 – aryl substituted semicarbazones of some terpenes ie , citral ( acyclic terpene ) , camphor ( bicyclic terpene ) and menthone ( monocyclic terpene ) were synthesized from substituted anilines , to meet the structural requirements essential for anticonvulsant activity . The structures of the synthesized terpene semicarbazones were confirmed by I.R. , H-NMR and elemental analysis. ...

The efficacy of 1-methylisatin 3-thiosemicarbazone for the inhibition of neurovaccinia virus in mice has been documented by D. J. Bauer and P. W. Sadler (Brit. J. Pharmacol. 15:101, 1960). The inhibition of adenovirus multiplication by this compound has been reported by D. J. Bauer and K. Apostolov (Science 154:796, 1966). The present communication pertains to the microbial conversion of 1-meth...

In the title compound, C(16)H(25)N(3)OS, the thio-semicarbazone group adopts an E configuration with respect to the C=N bond and is almost coplanar with the benzene ring, forming a dihedral angle of 9.3 (1)°. In the crystal packing, the mol-ecules lie along the a axis in an anti-parallel arrangement and are held in place by van der Waals inter-actions. As a consequence, there is relatively low ...

In the title compound, [Fe(2)Zn(C(5)H(5))(2)(C(7)H(7)N(3)S)(2)], the Cp rings of each ferrocene residue have a nearly eclipsed conformation. The two thio-semicarbazone ligands each coordinate the Zn atom in a bidentate mode via the N and S atoms, thereby defining a distorted tetra-hedral environment. N-H⋯S, N-H⋯N, C-H⋯S and C-H⋯N intra- and intermol-ecular inter-actions connect the mol-ecules i...

Cu (II) and Ni (II) complexes of general composition [ML2]X2 (M = Cu(II), Ni(II); X = Cl, NO3) were synthesized by the condensation of metal salts with semicarbazone / thiosemicarbazone derived from pdimethylaminobanzaldehyde. The metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, IR and atomic absorption spectral studies. On the b...

In the title hydrated mol-ecular salt, C13H14N3S+·HSO4-·H2O, the protonation of the azomethine N atom in sulfuric acid medium involves the formation of the bis-ulfate anion. The mol-ecular structure of the cation is obtained from the thiol tautomer of thio-semicarbazone wherein the naphthalene moiety and the conjugation of the bonds contribute to the planarity of the mol-ecular skeleton. In the...

Two-dimensional thin-layer chromatography was used to resolve cyclophosphamide metabolites present (a) in blood and urine of cyclophosphamide-treated rats and (b) after incuba tion of cyclophosphamide with hepatic microsomes, a hepatic 9000 X g supernatant fraction, or a model oxygenase system. Incubation of cyclophosphamide with rat hepatic microsomes yielded a single metabolite (aldophosphami...

A spectrophotometric method has been developed for the determination of Cu(II) using Acetophenone 2’,5’dihydroxy, semicarbazone as an extractive reagent .The reagent forms a colored complex which has been quantitatively extracted into n-Butanol at pH 5.6. The method obeys Beer’s law over a range of 1 to 10 ppm. The molar absorptivity is 2564.1 L molcm and Sandell’s sensitivity is 0.02484 μg cm ...