Sepsis is a subtype of systemic inflammatory response syndrome (SIRS), which is characterized by infection. Circulating microRNAs (miRNAs), including miR-150, miR-146a and miR-223, are potential biomarkers of sepsis. In this study, we demonstrated that measuring the relative expression of miR-146a/U6 in plasma, using the 2-ΔΔCt method, provides a method for differentiating between sepsis and no...

The paradigm of systemic inflammatory response syndrome-to-compensatory anti-inflammatory response syndrome transition implies that hyperinflammation triggers acute sepsis mortality, whereas hypoinflammation (release of anti-inflammatory cytokines) in late sepsis induces chronic deaths. However, the exact humoral inflammatory mechanisms attributable to sepsis outcomes remain elusive. In the fir...

OBJECTIVES To determine the effect of severe sepsis on monocyte tumor necrosis factor-α-converting enzyme baseline and inducible activity profiles. DESIGN Observational clinical study. SETTING Mixed surgical/medical teaching hospital ICU. PATIENTS Sixteen patients with severe sepsis, 15 healthy volunteers, and eight critically ill patients with noninfectious systemic inflammatory response...

Sepsis is a highly lethal syndrome with heterogeneous clinical manifestation that can be hard to identify and treat. Early diagnosis appropriate treatment are critical reduce mortality promote survival in suspected cases improve the outcomes. Several screening prediction systems have been proposed for evaluating early detection of patient deterioration, but efficacy still limited at individual ...

Antibiotic licensing studies remain a problem in neonates. The classical adult clinical syndrome-based licensing studies do not apply to neonates, where sepsis is the most common infection. The main obstacle to conducting neonatal antibiotic trials is a lack of consensus on the definition of neonatal sepsis itself and the selection of appropriate endpoints. This article describes the difficulti...

Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens. Acute respiratory distress syndrome (ARDS) is a devastating complication of severe sepsis, from which patients have high mortality. Advances in treatment modalities including lung protective ventilation, prone positioning, use of neuromuscular blockade, and extracorporeal membrane oxyge...

Background: Sepsis is a common and costly medical emergency, often leading to unplanned readmissions. The purpose of this quality improvement project integrate staff education, every 4 hours vital signs monitoring guided by sepsis screening score, structured response via process map reduce 30-day readmission rate 25% from baseline at hospital-based skilled nursing facility (HBSNF).Methods: This...

Objective. Studying of mutual role the main pathogenetic factors abdominal sepsis – inflammation origin and intraabdominal hypertension, from one side, endotoxicosis compression syndrome (ACS), other side.
 Materials methods. Into investigation 196 patients with were included, in whom after certain preliminary preparation operative procedure was done. The levels neutrophils, macrophages, i...

Despite several decades of research and phenomenal advances in technology and therapeutics, sepsis remains a catastrophic enigma. As a frequent cause of death, sepsis now rivals acute myocardial infarction. The longstanding therapeutic principles of early antibiotics use and supportive care have been difficult to improve upon. The authors conducted a concise review of pertinent literature on th...

Sepsis constitutes an important cause of hospital admission with a high mortality rate. Appropriate antibiotic therapy is the cornerstone of therapy in patients with sepsis. Although numerous studies have recommended early antibiotic initiation in severe sepsis or septic shock stages of sepsis syndrome, its role in treatment of patients with sepsis who have not entered these stages remains to b...