Surface-enhanced Raman spectroscopy (SERS) combines the high specificity of Raman scattering with high sensitivity due to an enhancement of the electromagnetic field by metallic nanostructures. However, the tyical fabrication methods of SERS substrates suffer from low throughput and therefore high costs. Furthermore, point-of-care applications require the investigation of liquid solutions and thu...

The mathematical background, based on a variation of the principal component analysis (PCA) method, is developed for the understanding of fluctuating multiple analyte single-molecule (SM) surface enhanced Raman scattering (SERS) signals; with emphasis on the bianalyte SERS technique developed recently. The method and its significance are presented to provide a systematic framework with which se...

A simple hydrothermal method was employed to synthesize AgFeO2 nanoparticles, which were utilized as substrates in SERS detection of Rhodamine 6G and 4-mercaptobenzoic acid. The magnetic properties of the products provided the capability of concentrating analyte molecules under an external magnetic field. The detection in aqueous solution has ensured the uniformity of the SERS signals and the r...

Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of full analytical SERS. Here, we introduce large-scale SERS particle screening (LSSPS), multiplexed widefield approach to characterization, which 500...

TiO2-coated Ag nanorods (Ag@TiO2 NRs) have been fabricated as multifunctional surface-enhanced Raman scattering (SERS) substrates. Uniform TiO2 shells could sufficiently protect the internal Ag NRs against oxidation and sulfuration, thus the temporal stability of SERS substrates was markedly improved. Meanwhile, due to the synergetic effect between crystalline TiO2 and Ag, the nanocomposites co...

Surfaced enhanced Raman scattering (SERS) nanotags operating with 1280 nm excitation were constructed from reporter molecules selected from a library of 14 chalcogenopyrylium dyes containing phenyl, 2-thienyl, and 2-selenophenyl substituents and a surface of hollow gold nanoshells (HGNs). These 1280 SERS nanotags are unique as they have multiple chalcogen atoms available which allow them to ads...

A controllable flower-like Au nanostructure array for surface-enhanced Raman scattering (SERS) was fabricated using the combined technique of the top-down approach of conventional photolithography and the bottom-up approach of electrodeposition. Au nanostructures with a mean roughness ranging from 5.1 to 49.6 nm were obtained by adjusting electrodeposition time from 2 to 60 min. The rougher Au ...

This work describes novel surface-enhanced Raman scattering (SERS) substrates based on ferroelectric periodically poled LiNbO3 templates. The templates comprise silver nanoparticles (AgNPs), the size and position of which are tailored by ferroelectric lithography. The substrate has uniform and large sampling areas that show SERS effective with excellent signal reproducibility, for which the fab...

Surface enhanced Raman scattering (SERS) effect is currently exploited as the basis of a new type of optical labels for in vivo investigation of the tissues, especially for early medical diagnostic. Silver colloidal nanoparticles decorated with chemisorbed cresyl violet molecular species could act as hybrid SERS labels. Their Raman scattering properties have been characterized here using differ...

Well-ordered Ag nanodot array on indium-tin-oxide (ITO) glass is adopted as a sensor platform based on surface-enhanced Raman scattering (SERS). SERS has attracted extensive attention in the development of sensitive chemical or biological sensors due to its property of the amplification of electromagnetic fields on a metal nanostructure. The key issue for the applications of SERS is to secure t...