background: considering the increasing rates of early hospital discharge and kernicterus in healthy full term newborns, timely identification of neonates at risk of severe hyperbilirubinemia is of great significance. the aim of this study was to investigate the predictive value of umbilical cord serum (ucs) bilirubin level for subsequent hyperbilirubinemia. moreover, we compared the predictive ...

This liquid-chromatographic procedure for determining bilirubin mono- and diester conjugates in normal serum is based on pre-analysis conversion of bilirubin monosugar and disugar conjugates to the corresponding methyl esters by alkaline methanolysis. Here, extracted unconjugated bilirubin, bilirubin monomethyl esters, bilirubin dimethyl ester, and internal standard are separated on a reversed-...

PURPOSE To investigate renal function estimated by markers in full-term newborns with hyperbilirubinemia. METHODS A total of 332 full-term newborns with hyperbilirubinemia and 60 healthy full-term newborns were enrolled. Total serum bilirubin, serum creatinine (Cr), serum blood urea nitrogen (BUN), serum cystatin C (Cys-C), urinary beta-2-microglobulin (β 2MG) index, and urinary N-acetyl-beta...

BACKGROUND Serum bilirubin may have potent antioxidant and cytoprotective effects. Serum bilirubin levels are inversely associated with several cardiovascular and metabolic endpoints, but their association with nonalcoholic fatty liver disease (NAFLD) has not been investigated except for a single cross-sectional study in a pediatric population. We assessed the prospective association between se...

OBJECTIVE This paper aims to evaluate the relations between serum bilirubin and essential trace elements in an adult population. RESULTS Demographic and clinical data were stratified according to the median of serum bilirubin concentrations (50th percentiles). There were statistical differences in regarding with age, body mass index, white blood count, hemoglobin, mean corpuscular hemoglobin,...

We examined serum bilirubin and low density lipoprotein cholesterol (LDL-C) as possible risk factors in 27 patients of myocardial infarction and 50 healthy individuals served as control. An inverse relationship between increase in total bilirubin and serum levels of LDL-C was observed. There is possibility of bilirubin playing a role in the pathogenesis of coronary heart disease through LDL-C l...

The yellow staining of basal ganglia (kernicterus) in some jaundiced newborn infants has been recognized for many years (1). The association between serum bilirubin concentration and kernicterus (2, 3), the isolation of bilirubin from kernicteric brains (4, 5), and the toxic effect of bilirubin in vitro upon oxygen uptake (6) and oxidative phosphorylation (7) are further evidence of a relations...

the gold standard to assess jaundice in neonates is the serum bilirubin measurement. blood sampling for the determination of total serum bilirubin (tsb) is painful for newborns and stressful for parents. the bilicheck®, a new transcutaneous bilirubinometer, is considered as a more accurate measurement of bilirubin compared to the previous bilirubinometers courtesy of its advanced technology. th...

BACKGROUND Elevated serum bilirubin concentrations protect against atherosclerotic diseases; however, it is not clear whether higher serum bilirubin concentrations in physiological ranges work in favor of the cardiovascular system in younger persons with no cardiovascular risk factors. Accordingly, we investigated the effects of high, intermediate, and low serum bilirubin concentrations on coro...

INTRODUCTION Previous studies have shown that serum bilirubin concentration is inversely associated with the risk of cardiovascular disease. The relationship between serum bilirubin concentration and left ventricular geometry, however, has not been investigated in patients with diabetes mellitus. METHODS In this cohort study, 158 asymptomatic patients with type 2 diabetes mellitus without ove...