Strong interest in copper homeostasis is due to the fact that copper is simultaneously a catalytic co-factor of the vital enzymes, a participant in signaling, and a toxic agent provoking oxidative stress. In mammals, during development copper metabolism is conformed to two types. In embryonic type copper metabolism (ETCM), newborns accumulate copper to high level in the liver because its excret...

background and aims: alcohol abuse is an important concern of many societies. hippocampal neurogenesis regulates abusing drugs in a positive manner. the aim of this study was to identify factors that regulate neurogenesis in isolation period that increase preference for alcohol and salt. materials and methods: in this study sixteen rats were randomly divided into two groups: pair (social) and i...

background & aim: in some studies, changes in trace elements of abuse of addictive substances have been mentioned. due to the effects of trace elements on the immune system and their effects on susceptibility to infectious agents, the purpose of this study was to investigate the effect(s) of morphine dependency on the concentration of trace elements (copper, zinc and manganese) levels in serum ...

BACKGROUND Essential micronutrients are important for maintenance of life. Deficiency of micronutrients is more likely to be encountered in children, and women studies are required to investigate the status of micronutrients in children and women. This study aimed to longitudinally evaluate changes in zinc, copper, and iron levels in breastfed infants and their mothers during the first year of ...

Zinc deficiency is clearly teratogenic in animals (1). The catabolism of maternal tissues during pregnancy, however, seems to protect the fetus from the teratogenic effects of hypozincemia (2). In humans, most evidence suggesting the importance of zinc during pregnancy comes from patients with acrodermatitis enteropathica, an inherited severe zinc deficiency state. These patients have spontaneo...

Four rat experiments were done to determine the effect of copper supplementation, in excess of the rat’s nutritional needs, on body weight and blood and liver lipids. Excess copper in the form of gluconate or yeast had no effect on weight gain. It significantly diminished the concentration of serum cholesterol and serum triglycerides. Excess copper raised the concentration of serum high density...

Diagnostic algorithms for Wilson's disease (WD) recommend the determination of serum ceruloplasmin in addition to the slit-lamp examination required to identify Kayser–Fleischer rings as clues in order to decide on or decline further testing, while measurements of total serum copper and/or ceruloplasmin-unbound (“free”) copper are of value in monitoring pharmacotherapy [1,2]. The direct measure...

BACKGROUND AND OBJECTIVES Biochemical derangements of microelements although reported in oral cancer is poorly understood in oral submucous fbrosis (OSMF). Hence, the present study was carried out to estimate and compare the serum copper and zinc levels among different histopathological stages of OSMF with that of healthy controls. MATERIALS AND METHODS Thirty histopathologically diagnosed ca...