OBJECTIVE Albuminuria and impaired glomerular filtration rate (GFR) are each associated with poor health outcomes among individuals with diabetes. Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population. RESEARCH DESIGN AND METHODS This is a cohort study among Cardiovascular Health Study participants with diabetes, mean age ...

BACKGROUND Serum creatinine concentration (Scr) and creatinine based GFR estimating equations (eGFRcr) are commonly used as an estimate of GFR. However, serum creatinine concentration is also influenced by non-GFR determinants. This case report presents two elderly patients with normal Scr but elevated serum cystatin C concentration (Scys) where the exclusive assessment of Scr would have lead t...

BACKGROUND AND OBJECTIVES Estimation of GFR in children from serum creatinine measures in regional databases is limited by a lack of height data. Furthermore, the ability of GFR estimating equations to quantify changes in GFR over time is unknown. Two methods of estimating GFR when height is unknown and the ability of several GFR equations to quantify GFR changes over time were evaluated. DES...

BACKGROUND Renal dysfunction is associated with increased morbidity and mortality in intensive care patients. In most cases the glomerular filtration rate (GFR) is estimated based on serum creatinine and the Modification of Diet in Renal Disease (MDRD) formula, but cystatin C-estimated GFR is being used increasingly. The aim of this study was to compare creatinine and MDRD and cystatin C-estima...

Creatinine-based glomerular filtration rate estimation (eGFRcr) has been improved and refined since the 1970s through both the Modification of Diet in Renal Disease (MDRD) Study equation in 1999 and the CKD Epidemiology Collaboration (CKD-EPI) equation in 2009, with current clinical practice dependent primarily on eGFR for accurate assessment of GFR. However, researchers and clinicians have rec...

BACKGROUND Creatinine calibration by clinical laboratories is important because variability among assays adversely affects the accuracy of glomerular filtration rate (GFR) estimation. We describe the calibration of creatinine assays used in the National Kidney Foundation Kidney Early Evaluation Program (KEEP). METHODS Creatinine values were requested for 200 samples at each of the 2 KEEP labo...

Sir, The paper by Kimmel et al. [1] concludes that cystatin C blood level variations are a more reliable parameter than serum creatinine increments for the diagnosis of contrastinduced nephropathy (CIN). However, this conclusion does not seem sufficiently supported by the data to us. Since the definition of CIN is based on serum creatinine variations, it is not clear what the meaning is of the ...

BACKGROUND Diabetic patients with chronic kidney disease (CKD), as defined by a reduced glomerular filtration rate (GFR), are at greater risk for cardiovascular and renal events and mortality. The aim of this study was to determine the prevalence of CKD among diabetic patients attending a hospital in southern Ethiopia, and to assess underdiagnosis of renal insufficiency among those with normal ...

A decline in renal function suggests progression of chronic kidney disease. This can be determined by measured GFR (e.g., iothalamate clearance), serum creatinine (SCr)-based GFR estimates, or creatinine clearance. A cohort of 234 patients with autosomal dominant polycystic kidney disease and baseline creatinine clearance>70 ml/min were followed annually for four visits. Iothalamate clearance, ...

chronic kidney disease (ckd) is an increasing cause of morbidity and mortality worldwide. prospective data on risk factors for ckd are few. hypertension is one of the risk factors for ckd. in the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(gfr), which limits its ability to detect impaired kidne...