There are only a few published studies confirming the ability of either urea or creatinine to induce adverse biochemical and physiological effects and there is not a defined level of serum creatinine that is lethal itself. Given the fact that by consulting the literature we did not find the highest level of creatinine in a surviving patient published in Croatia, we want to present the highest r...

background assessment of glomerular filtration rate (gfr) by common creatinine-based methods is potentially inaccurate in patients with cirrhosis. cirrhotic patients have several underlying conditions that contribute to falsely low serum creatinine concentrations, even in the presence of moderate to severe renal impairment. therefore creatinine-based methods usually overestimate true gfr in the...

Serum creatinine, a surrogate for both renal function and homocysteine generation, is a determinant of fasting plasma total homocysteine levels in coronary artery disease (CAD) patients. We hypothesized that among stable-CAD patients with normal creatinine levels (ie, </=1.4 mg/dL), serum cystatin C, a more sensitive indicator of glomerular filtration rate, would better predict fasting total ho...

background: methotrexate has an important role in treatment of acute leukemia. we measured methotrexate level in csf and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. materials and methods: one hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. patients were divided into two g...

We evaluated the safety of enalapril administration in 20 very old (76 +/- 7 years) patients with rapidly progressive congestive heart failure (deteriorating from New York Heart Association class 2 to class 4 on admission). They were all given increasing doses of enalapril regardless of concomitant diuretic therapy and state of hydration. Renal function deteriorated in four patients (group A) a...

Serum creatinine level is the most commonly used indices for assessment of glomerular filtration rate (GFR), even though these indices have been shown to have some limitations in clinical practice. We investigated the diagnostic efficacy of serum cystatin C compared to that of serum creatinine levels and identified the relating factors associated with changes in serum cystatin C levels in gout ...

the aim of this study was to investigate c-reactive protein (crp) level in preeclampsia (pe) and its association with the severity of the disease. this cross-sectional study included 43 women with mild pe, 43 women with severe pe, and 43 healthy pregnant. they were selected in the third trimester of pregnancy in the afzalipour hospital, kerman, iran, from march 2006 to march 2007. mean diastoli...

PURPOSE To evaluate the incidence of secondary hyperparathyroidism (SH) among postmenopausal women with end-stage knee osteoarthritis scheduled for total knee replacement (TKR). METHODS 283 Caucasian postmenopausal women aged 49 to 81 (mean, 70) years with end-stage idiopathic knee osteoarthritis were scheduled to undergo primary TKR. They had been menopausal for 7 to 31 (mean, 19) years. The...