A marked imbalance of the two light chain types of immunoglobulins was observed in two young male adults suffering from primary hypogammaglobulinemia and intrinsic factor-deficient pernicious anemia. In one patient, the i/A light chain ratio of serum immunoglobulins was 0.01; in the other it was approximately 6 (normal value, 1.8 ± 0.3). This light chain imbalance was found within each of the t...

The purpose of this investigation was to study the distribution and levels of the following immunoglobulins, IgA, IgG, and IgM ,in sera and in some secretions of monkeys (M. fascicularis). IgG, IgA, and IgM were isolated from monkey serum and secretory IgA was separated from monkey milk by combined gel filtration and ion-exchange chromatography. These pure preparations served as standards to qu...

The presence of active transforming growth factor-beta (TGF-beta) in serum has not been widely accepted. In particular, although at least five studies have concluded that active TGF-beta is present in normal human plasma and serum, assays that use the extracellular domain of the TGF-beta type II receptor as a capture agent have given contradictory results. We show that there is an antagonist pr...

Abstract The Bovine Respiratory Complex (BRC) significantly impacts morbidity and mortality in dairy calves between 1 3 months of age, called the immunological gap. receive colostrum milk immunoglobulins; however, these animals are still developing their specific immune system cannot present a robust active humoral response. Vaccines against intranasal BRC recommended for from first week age; a...

Immunoglobulins are part of the humoral immunity response against foreign antigens. Their blood levels could be influenced by different agents, including food supplements as Aphanizomenon flos-aquae (AFA), Propolis, substances as Fucoidan and herbal extracts. Purpose. To evaluate whether Fucoidan, AFA, a total leaf extract of Haberlea rhodopensis and Propolis augment the IgG and IgM levels into...

Monoclonal gammopathies reflect conditions in which abnormal amounts of immunoglobulins are produced by a clone that developed from a single pro-B germ cell. The condition may reflect a disease process or be benign. The primary purpose of this review is to emphasize routine clinical laboratory techniques that currently are recommended for use in identifying monoclonal gammopathies from serum an...