The beta-lactam susceptibilities of 65 strains of Streptococcus pneumoniae for which penicillin MICs covered a broad range were assessed. The order of potency was amoxicillin (AMX) = amoxicillin-clavulanate (AMC) > penicillin G > cefpodoxime (CPO) > cefuroxime (CXM) > cefprozil > cefaclor > loracarbef > cefixime. No decrease in susceptibility was seen following repeated subculture of two penici...

All beta-lactam sensitive bacteria contain enzymatic penicillin binding proteins (PBPs), which are membrane-bound enzymes and targets of beta-lactam antibiotics. In this work evaluation of the significance of PBPs in immune response to benzylpenicillin was presented. 35 patients with allergic reactions to penicillin and 17 subjects without penicillin allergy, but exposed, were studied. Prolifer...

There is at present considerable interest in the newer forms of penicillin which ha^ been introduced since the isolation of the penicillin nucleus 6-amino penicillanic in 1959 made possible, by substitution of differing side chains, the production of 3 whole range of new penicillin compounds. This trial was designed to compare the clinical effectiveness of two of these, phenethicillin and propi...

The administration of benzylpenicillin (penicillin) to man has been shown to induce the synthesis of antibodies of several distinct haptenic specificities and of several molecular classes (1-13). Specifically, skin-sensitizing antibodies of benzylpenicilloyl (BPO) haptenic specificity (1-7, 11) and of the minor determinant specificities (6, 7, 11) have been demonstrated. Also, BPO-specific anti...

BACKGROUND An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease. METHODS We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after t...

Patel et al. (4) compared the serum bactericidal titers (SBTs) and the time serum drug concentrations remained above the MICs (T . MIC) of ceftizoxime and cefotaxime against three intermediately penicillin-resistant Streptococcus pneumoniae isolates. MICs were # 1.0 mg/ml, SBTs were . 1:2, and T . MIC exceeded 50% of dosage intervals. They concluded that ceftizoxime’s longer T . MIC compensates...

The recent report, “Serum prolactin level in psoriasis”, is very interesting 1. Ghiasi et al. concluded that “it seems that while intracutaneous prolactin may contribute to the pathogenesis of psoriasis, the probable role of pituitary-produced circulating prolactin in the disease process needs further investigation .” There are some concerns on this report. First, although Ghiasi et al. have st...

Sows (n = 126; 228 ± 30.1 kg) were administered daily IM doses of penicillin G procaine (33 000 IU/kg bw; 5× the label dose) for 3 consecutive days using three different administration patterns. Within treatment, six sows each were slaughtered on withdrawal day 5, 10, 15, 20, 25, 32, and 39. Tissues (injection site, kidney, liver, skeletal muscle) or body fluids (serum and urine) were screened ...

BACKGROUND This study was designed to evaluate the population pharmacokinetics (popPK) of penicillin G in patients with infective endocarditis and establish a dosage regimen based on pharmacokinetic data and clinical outcome. METHOD Forty-six serum penicillin G samples from 25 individuals were analyzed using a nonlinear mixed-effects model. popPK were estimated using a one-compartment model. ...