Ixabepilone (Ixempra) is a member of a new class of cytotoxic agents, the epothilones. Epothilones promote tubulin polymerization in vitro and demonstrate antitumor activity. This article reviews the preclinical and clinical data that have led to the approval of ixabepilone for patients with locally advanced or metastatic breast cancer for whom anthracycline and taxane treatments have failed.

This Book Review is brought to you for free and open access by the Tampa Library at Scholar Commons. It has been accepted for inclusion in Genocide Studies and Prevention: An International Journal by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. Recommended Citation Powell, Christopher Ph.D. (2015) "Book Review: Warning Signs of Gen...

objective: the aim of this study is to measure the effect of different condensation pressure on the microleakage of mineral trioxide aggregate (mta).  methods: this study was an invitro study. a total of 55 single rooted straight-canal human extracted sound teeth free of cracks or calcification were selected. teeth were sectioned from cej region at 3 mm above the root apex. remaining specimens ...

Students of social movements have long struggled with the question how relatively abstract political opportunities, such as elite divisions, affect unorganized activists without much knowledge of politics. We argue that the relationship between institutional opportunities and decisions to mobilize may take the form of trickle-down politics. In this view activists are affected by political oppor...

In order to increase the efficiency of the conveyance of the granular solids, a new experimental set-up is designed. The test rig has longitudinal trapezoidal slots in its conveying pipes. Through experimentation, a correlation for friction factor in terms of solid mass flow rate, fluid flow rate and Froude number is presented. It is shown that the mixture friction factor for pipes with inn...