Teleost fishes are the most species-rich clade of vertebrates and feature an overwhelming diversity of sex-determining mechanisms, classically grouped into environmental and genetic systems. Here, we review the recent findings in the field of sex determination in fish. In the past few years, several new master regulators of sex determination and other factors involved in sexual development have...

Eight patients with XXXXY sex chromosomes are on record (Fraccaro, Kaijser, and Lindsten, I960; Miller, Breg, Schmickel, and Tretter, I96I; Fraser, Boyd, Lennox, and Dennison, I96I; Fraccaro, Klinger, and Schutt, I962; Barr, Carr, Pozsonyi, Wilson, Dunn, Jacobson, and Miller, I962; Pfeiffer, I962; Schade, Sch6ller, and T6berg, I963). In addition two similar patients with a mosaic pattern have b...

Background: Cirrhinus mrigala, one of the important fish widely consumed in India, was used for karyological observations and to evaluate the toxic effect of butachlor, an extensively used herbicide in rice fields in terms of chromosomal aberration test. Methods: Fishes were collected from “National Fish Seed Farm” Jyotisar with mean body weight of 20-50g. The experimental fishes were kept i...

a large number of simple or complex translocation involving the cml and aml chromosomal abnormalities has been described. this study was aimed to investigate the complex chromosome aberrations in the series of myeloid malignancies including cml and aml. the present report deals analyzed 187 consecutive with cml and aml patients, using methotrexate  cell synchronization and  un-stimulated cultur...

7. 1. Summary Vertebrates have various sex determining mechanisms. These have been broadly classified as either genotypic sex determination (GSD) or environmental sex determination (ESD). This terminology, however, may obscure the fact that mixtures between genotypic and environmental sex determination exist, or that genotypic and environmental sex determination may, in fact, be the extremes of...

background: the present study has been carried out to investigate the effects of preovulatory stage gamma-irradiation of female mice in the absence or presence of vitamin e on numerical chromosome abnormalities in 8-cell embryos after mating with non-irradiated males. materials and methods: the 8-11 weeks adult female nmri mice were whole body irradiated at preovulatory stage (post pmsg injecti...

Cytogenetic analysis of short-term cultures was carried out on 109 lipomas from 92 patients. Clonal chromosomal abnormalities were pres ent in 50% of the tumors analyzed. Based on the results, three main Cytogenetic groups were identified and included: (a) tumors with normal karyotypes, (b) tumors with abnormalities involving region ql3-15 on chromosome 12, and (c) tumors with other clonal aber...

Cytogenetic analysis of short-term cultures was carried out on 109 lipomas from 92 patients. Clonal chromosomal abnormalities were present in 50% of the tumors analyzed. Based on the results, three main cytogenetic groups were identified and included: (a) tumors with normal karyotypes, (b) tumors with abnormalities involving region q13-15 on chromosome 12, and (c) tumors with other clonal aberr...

Inversions are structural chromosome abnormalities that may be associated with infertility, multiple miscarriage and chromosomally unbalanced offspring. Preimplantation genetic diagnosis (PGD) with subtelomeric probes was used to select for transfer only those embryos that were normal or balanced for three pericentric inversions. In contrast to previous protocols the present procedure allows th...

OBJECTIVE To analyze the chromosomal abnormalities in couples with history of recurrent abortions. DESIGN Retrospective study. SETTING Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan. PATIENTS Three hundred couples with history of recurrent abortions. MAIN OUTCOME MEASURE Structural chromosomal abnormalities in carrier couples. RESUL...