a 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate. the assumed displacement field accounts for non-linear variation of in-plane displacements as well as transverse displacement through the plate thickness. the condition of zero ...

Cardiovascular development is directed or modulated by genetic and epigenetic factors. The latter include blood flow-related shear stress and blood pressure-related circumferential strain. This review focuses on shear stress and its effects on endothelial cells lining the inner surfaces of the heart and blood vessels. Flow characteristics of the embryonic blood, like velocity, viscosity and per...

this paper presents a novel formulation and numerical solutions for adhesively bonded composite joints with non-linear (softening) adhesive behaviour. the presented approach has the capability of choosing arbitrary loadings and boundary conditions. in this model adherends are orthotropic laminates that obey classical lamination theory. the stacking sequences can be either symmetric or asymmetri...

Recent investigations indicate that the initial event in the pathogenesis of atherosclerosis involves an (auto)immunologic injury to the vessel wall. Heat shock proteins (hsps), which are expressed on the endothelial cell surface, constitute possible autoantigens. After being exposed to shear stress of 30 dyne/cm(2) in vitro by means of a rotational viscometer, human umbilical vein endothelial ...

Recent investigations indicate that the initial event in the pathogenesis of atherosclerosis involves an (auto)immunologic injury to the vessel wall. Heat shock proteins (hsps), which are expressed on the endothelial cell surface, constitute possible autoantigens. After being exposed to shear stress of 30 dyne/cm in vitro by means of a rotational viscometer, human umbilical vein endothelial cel...

Matrix metalloproteinase (MMP)-1, 2, with their endogenous inhibitors, tissue inhibitor of metalloproteinase (TIMP)-1, 2 are critical for extracellular matrix remodeling in human periodontal ligament (PDL) and their expression are sensitive to mechanical stresses. Shear stress as the main type of mechanical stress in tooth movement is involved in matrix turnover. However, how shear stress regul...

To investigate whether the production of colony-stimulating factors (CSFs) by vascular endothelial cells is regulated by hemodynamic force, we exposed cultured human umbilical vein endothelial cells (HUVECs) to controlled levels of shear stress in a flow-loading apparatus and examined changes in the production of CSFs at both the protein and mRNA level. Exposure of HUVECs to a shear stress of 1...

This paper focuses on a hydraulic radius separation approach used to calculate the boundary shear stress in terms of bed and wall shear stress proposed in a trapezoidal channel. The average bed and sidewall shear stress in smooth trapezoidal open channels are derived after using Guo & Julien (2005) early equations taking a part of an investigation to cover both rectangular and trapezoidal chann...

shear modulus and damping ratio are important input parameters in dynamic analysis. a series of resonant column tests was carried out on pure clays and sand-clay mixtures prepared at different densities to investigate the effects of aggregate content, confining stress, void ratio and clay plasticity on the maximum shear modulus and minimum damping ratio. test results revealed an increase in the...

We tested the hypothesis that steady laminar shear stress activates the glucocorticoid receptor (GR) and its transcriptional signaling pathway in an effort to investigate the potential involvement of GR in shear stress-induced antiatherosclerosis actions in the vasculature. In both bovine aortic endothelial cells (BAECs) and NIH3T3 cells expressing GFP-GR chimeric protein, wall shear stress of ...