Heat shock of living tissue induces the synthesis of a unique group of proteins, the heat shock proteins. In plants, the major group of heat shock proteins has a molecular mass of 15 to 25 kilodaltons. Accumulation of these proteins to stainable levels has been reported in only a few species. To examine accumulation of the low molecular weight heat shock proteins in a broader range of species, ...

purpose: in order to express human granulocyte-macrophage colony stimulating factor (hgm-csf) under heat shock. materials and methods: two expression plasmids were constructed based on pbc(sk) plasmid. the expression cassettes in the two plasmids are equipped with a 75 base pair fragment, derived from the pl promoter of the bacteriophage lambda (λ). the plasmids also contain a temperature muta...

KEY WORDS heat shock proteins; cytokines; heat shock factor t has become clear in recent years that, heat shock proteins (hsps) play a major role in the acute in-flammatory response and inflammatory diseases. 1,z Heat shock proteins were originally characterized as a highly conserved group of proteins involved in the response of cellular organisms to stresses such as heat shock. 3,4 These prote...

The book Heat Shock Proteins (HSP) in Molecular and Cellular Biology of Human Diseases Volume 28 provides the most comprehensive up-to-date review on new exciting therapies that utilize mechanisms based heat shock response targeting various stress proteins as a promising therapeutic strategy for wide variety human diseases including all types cancers inflammatory diseases. Using an integrative ...

Background: OCT4B1, a variant of OCT4, is expressed in both cancer cells and tissues. This variant has a main role in the regulation of both apoptotic and stress (heat-shock proteins) pathways. The aim of this study was to investigate the effects of OCT4B1 silencing on the expression of small heat-shock proteins (sHSPs)in three human tumor cell lines. Methods:...

KEY WORDS heat shock proteins; cytokines; heat shock factor t has become clear in recent years that, heat shock proteins (hsps) play a major role in the acute in-flammatory response and inflammatory diseases. 1,z Heat shock proteins were originally characterized as a highly conserved group of proteins involved in the response of cellular organisms to stresses such as heat shock. 3,4 These prote...

lstituto di Microbiologia’ and lstituto di Clinica Dermosif ilopaticaz, Seconda Universita degli Studi di Napoli, Facolta di Medicina e Chirurgia, Larghetto S.Aniello a Caponapoli, 2,801 38 Napoli, Italy Bacterial heat-shock proteins (HSPs) from Escherichia co/i (GroES, GroEL and DnaK) were studied for their ability to induce by themselves the expression and release of tumour necrosis factor-a ...